{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Christensen ND"],"funding":["American Cancer Society","NIDCR NIH HHS","Penn State Hershey Cancer Institute","NCI NIH HHS"],"pagination":["109321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9340668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["333"],"pubmed_abstract":["HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. We have recently developed a mouse papillomavirus (MmuPV1) oral mucosal infection model that provides opportunities to test, for the first time, the hypothesis that tobacco carcinogens are co-factors that can impact the progression of oral papillomas to squamous cell carcinoma (SCC). Four cohorts of mice per sex were included: (1) infected with MmuPV1 and treated orally with DMSO-saline; (2) infected with MmuPV1 and treated orally with the tobacco carcinogen, dibenzo[def,p]chrysene (DBP); (3) uninfected and treated orally with DMSO-saline, and ("],"journal":["Chemico-biological interactions"],"pubmed_title":["The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections."],"pmcid":["PMC9340668"],"funding_grant_id":["R21 DE028650","R01 CA173465"],"pubmed_authors":["Aliaga C","Balogh KK","Li J","Stairs DB","Shearer D","El-Bayoumy K","Chen KM","Atkins H","Christensen ND","Hu J","Walter V","Viscidi R","Sun YW","Gowda K","Amin S","Brendle SA"],"additional_accession":[]},"is_claimable":false,"name":"The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections.","description":"HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. We have recently developed a mouse papillomavirus (MmuPV1) oral mucosal infection model that provides opportunities to test, for the first time, the hypothesis that tobacco carcinogens are co-factors that can impact the progression of oral papillomas to squamous cell carcinoma (SCC). Four cohorts of mice per sex were included: (1) infected with MmuPV1 and treated orally with DMSO-saline; (2) infected with MmuPV1 and treated orally with the tobacco carcinogen, dibenzo[def,p]chrysene (DBP); (3) uninfected and treated orally with DMSO-saline, and (","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-19T06:02:20.091Z","creation":"2025-04-19T06:02:20.091Z"},"accession":"S-EPMC9340668","cross_references":{"pubmed":["33186600"],"doi":["10.1016/j.cbi.2020.109321"]}}