biostudies-literatureChristensen NDAmerican Cancer SocietyNIDCR NIH HHSPenn State Hershey Cancer InstituteNCI NIH HHS109321https://www.ebi.ac.uk/biostudies/studies/S-EPMC9340668biostudies-literatureUnknown333HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. We have recently developed a mouse papillomavirus (MmuPV1) oral mucosal infection model that provides opportunities to test, for the first time, the hypothesis that tobacco carcinogens are co-factors that can impact the progression of oral papillomas to squamous cell carcinoma (SCC). Four cohorts of mice per sex were included: (1) infected with MmuPV1 and treated orally with DMSO-saline; (2) infected with MmuPV1 and treated orally with the tobacco carcinogen, dibenzo[def,p]chrysene (DBP); (3) uninfected and treated orally with DMSO-saline, and (Chemico-biological interactionsThe environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections.PMC9340668R21 DE028650R01 CA173465Aliaga CBalogh KKLi JStairs DBShearer DEl-Bayoumy KChen KMAtkins HChristensen NDHu JWalter VViscidi RSun YWGowda KAmin SBrendle SAfalseThe environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections.HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. We have recently developed a mouse papillomavirus (MmuPV1) oral mucosal infection model that provides opportunities to test, for the first time, the hypothesis that tobacco carcinogens are co-factors that can impact the progression of oral papillomas to squamous cell carcinoma (SCC). Four cohorts of mice per sex were included: (1) infected with MmuPV1 and treated orally with DMSO-saline; (2) infected with MmuPV1 and treated orally with the tobacco carcinogen, dibenzo[def,p]chrysene (DBP); (3) uninfected and treated orally with DMSO-saline, and (2021-01-01T00:00:00Z2021 Jan2025-04-19T06:02:20.091Z2025-04-19T06:02:20.091ZS-EPMC93406683318660010.1016/j.cbi.2020.109321