biostudies-literatureNoguchi-Shinohara MJapan Agency for Medical Research and DevelopmentJapan Society for the Promotion of Science12129https://www.ebi.ac.uk/biostudies/studies/S-EPMC9343640biostudies-literatureUnknown12(1)Physical frailty has been associated with adverse outcomes such as dementia. However, the underlying structural brain abnormalities of physical frailty are unclear. We investigated the relationship between physical frailty and structural brain abnormalities in 670 cognitively unimpaired individuals (mean age 70.1 years). Total brain volume (TBV), hippocampal volume (HV), total white matter hypointensities volume (WMHV), and estimated total intracranial volume (eTIV) on the 3D T1-weighted images were automatically computed using FreeSurfer software. Participants were divided into two states of physical frailty (robust vs. prefrail) based on the revised Japanese version of the Cardiovascular Health Study criteria. The multivariable-adjusted mean values of the TBV-to-eTIV ratio was significanScientific reportsAssociation of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study.PMC9343640JP17KO9795dk0207025Tatewaki YTaki YIwasa KThyreau BNoguchi-Shinohara MShibata MYamada MYuki-Nozaki SNinomiya TKomai KOno KHata JOhara TYokogawa MfalseAssociation of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study.Physical frailty has been associated with adverse outcomes such as dementia. However, the underlying structural brain abnormalities of physical frailty are unclear. We investigated the relationship between physical frailty and structural brain abnormalities in 670 cognitively unimpaired individuals (mean age 70.1 years). Total brain volume (TBV), hippocampal volume (HV), total white matter hypointensities volume (WMHV), and estimated total intracranial volume (eTIV) on the 3D T1-weighted images were automatically computed using FreeSurfer software. Participants were divided into two states of physical frailty (robust vs. prefrail) based on the revised Japanese version of the Cardiovascular Health Study criteria. The multivariable-adjusted mean values of the TBV-to-eTIV ratio was significan2022-01-01T00:00:00Z2022 Aug2025-04-26T11:58:17.133Z2025-04-06T13:53:56.024ZS-EPMC93436403591513010.1038/s41598-022-16190-7