{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Trung NB"],"funding":["Ministry of Science and Technology, Taiwan"],"pubmed_abstract":["Nile tilapia (<i>Oreochromis niloticus</i>) is one of the most important food fish in the world. However, the farming industry has encountered significant challenges, such as pathogen infections. Toll-like receptors (TLRs) play an essential role in the initiation of the innate immune system against pathogens. Sterile alpha and TIR motif-containing protein 1 (SARM1) is one of the most evolutionarily conserved TLR adaptors, and its orthologs are present in various species from worms to humans. SARM1 plays an important role in negatively regulating TIR domain-containing adaptor proteins inducing IFNβ (TRIF)-dependent TLR signaling in mammals, but its immune function remains poorly understood in fish. In this study, <i>O. niloticus</i> SARM1 (<i>OnSARM1</i>) was cloned and its evolutionary sta"],"journal":["Frontiers in immunology"],"pagination":["940877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9344004"],"repository":["biostudies-literature"],"pubmed_title":["Sterile alpha and TIR motif-containing protein 1 is a negative regulator in the anti-bacterial immune responses in nile tilapia (<i>Oreochromis niloticus</i>)."],"pmcid":["PMC9344004"],"pubmed_authors":["Hsueh HY","Wangkahart E","Loh JY","Lee PT","Trung NB","Nguyen TP","Wong ASF"],"additional_accession":[]},"is_claimable":false,"name":"Sterile alpha and TIR motif-containing protein 1 is a negative regulator in the anti-bacterial immune responses in nile tilapia (<i>Oreochromis niloticus</i>).","description":"Nile tilapia (<i>Oreochromis niloticus</i>) is one of the most important food fish in the world. However, the farming industry has encountered significant challenges, such as pathogen infections. Toll-like receptors (TLRs) play an essential role in the initiation of the innate immune system against pathogens. Sterile alpha and TIR motif-containing protein 1 (SARM1) is one of the most evolutionarily conserved TLR adaptors, and its orthologs are present in various species from worms to humans. SARM1 plays an important role in negatively regulating TIR domain-containing adaptor proteins inducing IFNβ (TRIF)-dependent TLR signaling in mammals, but its immune function remains poorly understood in fish. In this study, <i>O. niloticus</i> SARM1 (<i>OnSARM1</i>) was cloned and its evolutionary sta","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T15:52:10.703Z","creation":"2024-11-15T22:37:07.623Z"},"accession":"S-EPMC9344004","cross_references":{"pubmed":["35928810"],"doi":["10.3389/fimmu.2022.940877"]}}