{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Wang H"],"pubmed_abstract":["Alzheimer's disease (AD) is complex and highly heterogeneous. Less than 10% of AD cases are early-onset (EOAD) caused by autosomal dominantly inherited mutations in amyloid precursor protein (APP), presenilin 1 (PS1), or presenilin 2 (PS2), each of which can increase Aβ generation and, thus, amyloid plaques. The remaining 90% of cases of AD are late-onset (LOAD) or sporadic. Intense research efforts have led to identification of many genes that increase the risk of AD. An IQ motif containing protein K (IQCK) was recently identified by several investigators as an Alzheimer's disease risk gene. However, how IQCK increases AD risk is completely unknown. Since IQCK is a novel gene, there is limited information on its physiological characterization. To understand its role in AD, it is first imp"],"journal":["Frontiers in cellular neuroscience"],"pagination":["954071"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9344928"],"repository":["biostudies-literature"],"pubmed_title":["Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease."],"pmcid":["PMC9344928"],"pubmed_authors":["Chand HS","Devadoss D","Wang H","Nair M","Lakshmana MK"],"additional_accession":[]},"is_claimable":false,"name":"Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease.","description":"Alzheimer's disease (AD) is complex and highly heterogeneous. Less than 10% of AD cases are early-onset (EOAD) caused by autosomal dominantly inherited mutations in amyloid precursor protein (APP), presenilin 1 (PS1), or presenilin 2 (PS2), each of which can increase Aβ generation and, thus, amyloid plaques. The remaining 90% of cases of AD are late-onset (LOAD) or sporadic. Intense research efforts have led to identification of many genes that increase the risk of AD. An IQ motif containing protein K (IQCK) was recently identified by several investigators as an Alzheimer's disease risk gene. However, how IQCK increases AD risk is completely unknown. Since IQCK is a novel gene, there is limited information on its physiological characterization. To understand its role in AD, it is first imp","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T14:08:47.492Z","creation":"2024-11-12T14:36:45.806Z"},"accession":"S-EPMC9344928","cross_references":{"pubmed":["35928571"],"doi":["10.3389/fncel.2022.954071"]}}