{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nguyen MQ"],"funding":["Naito Foundation","Takeda Science Foundation","NOVARTIS Foundation","Japan Society for the Promotion of Science"],"pagination":["bio059024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9346286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(7)"],"pubmed_abstract":["Actin-based protrusions called cytonemes are reported to function in cell communication by supporting events such as morphogen gradient establishment and pattern formation. Despite the crucial roles of cytonemes in cell signaling, the molecular mechanism for cytoneme establishment remains elusive. In this study, we showed that the leukocyte common antigen-related (LAR) receptor protein tyrosine phosphatase plays an important role in cytoneme-like protrusion formation. Overexpression of LAR in HEK293T cells induced the formation of actin-based protrusions, some of which exceeded 200 µm in length and displayed a complex morphology with branches. Upon focusing on the regulation of LAR dimerization or clustering and the resulting regulatory effects on LAR phosphatase activity, we found that lo"],"journal":["Biology open"],"pubmed_title":["Cytoneme-like protrusion formation induced by LAR is promoted by receptor dimerization."],"pmcid":["PMC9346286"],"funding_grant_id":["25293043","JSPS KAKENHI 19K22471","20H03414","JSPS KAKENHI 21390052","17H04014","JSPS KAKENHI 19K06923","JSPS KAKENHI 26430017"],"pubmed_authors":["Yasumura M","Iguchi T","Taniguchi M","Nguyen MQ","Sato M"],"additional_accession":[]},"is_claimable":false,"name":"Cytoneme-like protrusion formation induced by LAR is promoted by receptor dimerization.","description":"Actin-based protrusions called cytonemes are reported to function in cell communication by supporting events such as morphogen gradient establishment and pattern formation. Despite the crucial roles of cytonemes in cell signaling, the molecular mechanism for cytoneme establishment remains elusive. In this study, we showed that the leukocyte common antigen-related (LAR) receptor protein tyrosine phosphatase plays an important role in cytoneme-like protrusion formation. Overexpression of LAR in HEK293T cells induced the formation of actin-based protrusions, some of which exceeded 200 µm in length and displayed a complex morphology with branches. Upon focusing on the regulation of LAR dimerization or clustering and the resulting regulatory effects on LAR phosphatase activity, we found that lo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-22T01:50:18.951Z","creation":"2024-11-08T23:29:54.722Z"},"accession":"S-EPMC9346286","cross_references":{"pubmed":["35735010"],"doi":["10.1242/bio.059024"]}}