{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(8)"],"submitter":["Di Carlo S"],"pubmed_abstract":["GM-CSF is a potent inflammatory cytokine regulating myeloid cell differentiation, hematopoiesis, and various other functions. It is functionally associated with a number of inflammatory pathologies including rheumatoid arthritis and inflammatory bowel disease. GM-CSF has been found to promote NLRP3-dependent IL-1β secretion, which may have a significant role in driving inflammatory pathologies. However, the molecular mechanisms remain unknown. Here, we show that GM-CSF induces IL-1β secretion through a ROS-dependent pathway. TNF is required for reactive oxygen species (ROS) generation that strikingly does not promote NLRP3 activation, but instead drives ubiquitylation of IL-1β, promoting its cleavage through basal NRLP3 activity. GM-CSF regulates this pathway through suppression of antioxi"],"journal":["EMBO reports"],"pagination":["e54226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9346485"],"repository":["biostudies-literature"],"pubmed_title":["GM-CSF suppresses antioxidant signaling and drives IL-1β secretion through NRF2 downregulation."],"pmcid":["PMC9346485"],"pubmed_authors":["Hacker G","Di Carlo S","Gentle IE"],"additional_accession":[]},"is_claimable":false,"name":"GM-CSF suppresses antioxidant signaling and drives IL-1β secretion through NRF2 downregulation.","description":"GM-CSF is a potent inflammatory cytokine regulating myeloid cell differentiation, hematopoiesis, and various other functions. It is functionally associated with a number of inflammatory pathologies including rheumatoid arthritis and inflammatory bowel disease. GM-CSF has been found to promote NLRP3-dependent IL-1β secretion, which may have a significant role in driving inflammatory pathologies. However, the molecular mechanisms remain unknown. Here, we show that GM-CSF induces IL-1β secretion through a ROS-dependent pathway. TNF is required for reactive oxygen species (ROS) generation that strikingly does not promote NLRP3 activation, but instead drives ubiquitylation of IL-1β, promoting its cleavage through basal NRLP3 activity. GM-CSF regulates this pathway through suppression of antioxi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-18T15:36:18.953Z","creation":"2025-02-19T03:58:05.347Z"},"accession":"S-EPMC9346485","cross_references":{"pubmed":["35695080"],"doi":["10.15252/embr.202154226"]}}