biostudies-literatureConway Morris AEuropean Society of Intensive Care MedicineMedical Research CouncilNational Institute for Health Research (NIHR)Academy of Medical Sciences236https://www.ebi.ac.uk/biostudies/studies/S-EPMC9347163biostudies-literatureUnknown26(1)<h4>Background</h4>The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.<h4>Methods</h4>This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020)Critical care (London, England)Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set.PMC9347163CL-2018-14-002SGL023\1048MR/V006118/1NIHR302841Florio GMeybohm PGalarza LKrupa IEksarko POsterlind JCabrera LSDereli NElbers PWGElbuzidi ASSulemanji DFraile VLegaristi NDe Buyser WVan Leemput JFerrando CBihariesingh-Sanchit RTeplykh BParra JPAJain SScholten HHerrmann JKviatkovske OKatz DGarrioch SKaya ESantos ASerrano ADe Waele JElrabi OPovoa PChrysanthopoulou EKuhail ABezzi MDe Waele EDe Rosa SParra-Tanoux DGonzalez FMVan Hecke JAbdalla MMahmoodpoor ASilva CMumelj LAssal HSo RKLAbad-Motos ABerkius JLinde FALahmer TDavydova LAntonelli MPopov EPotter EVolta CAMcMahon STorlinski TGolden DNoto AReyes LFTeruel SYGottin LAlsabbah Ade Wijs CVaccarini BMullhi RHall CDonnelly ASales GVlachou ANeporada EFichtner Fvan der Heiden EHo VKYilmaz MBakdach DKhlafalla SHalacli BKuhn KFRamires TVasileiadou GGonzalez DRWilting RArabi YLumlertgul NPerez-Araos RElay GHammouda AFerrari FBde Groot MDe Corte TGrip JKoulenti DPiagnerelli MReidinga ACAlwraidat MEyupoglu SMarczin NBarling DCamoes JHagan SBulpa PHusain AIzdes SDe Jesus MFGrunow JJSantos MLRana MDelgado MCMEspina LFMengi TShuker BLabarca EBerezo-Garcia JAElhadi MSchaller SDonadello KRodriguez-Ruiz EWeiss BJubb AMensink RYepes DBethlehem CStubenrauch PEllis CGrauslyte LCanedo NDementienko MValverde VHConcha PJones NPetrisor CDel Carmen Lorente Conesa MAl-Bayati SMeshchaninova SRomeu JMBallesteros JPPPravia OVBMartin BCFoulon PMartinez FSavi MPatricio PHaentjens LFuest KGrady BGalal IOliveira AGeagea Avon Seth MHigenbottam CVReinhard VGarcia RRSpieth PNielsen NLarranaga LPopova KVarela IYMThoral PQayyum ACeruti SBoer SDLucas JHHernandez AMPoyat CCornet ADGoncalves CFranquesa-Gonzalez Ede Jong CEldaly AAllan JPapamichalis PBaccanelli FDe Schryver NPerez-Torres DCecconi MPyregov AStipic SSAljuhani OGraf JFerrigno GLoveleena GIlieva VAlfishawy MHanlon Kde Jong BAzab MAJog SLago GPerez-Calvo CAdriao DCollin VDean JTAhmed ACuenca-Rubio CCrapelli GBSoultati ISpronk PEAlasia DAlkhatteb MCunha PDe Backer DTirapegui FIsoni PSahin ASPolati EKalvit KCatalan-Monzon IBeck OAl-Sadawi MBilir YSri-Chandana CAkkari AREroglu ACook MConway Morris AZoerner FTomak YBurgos CVCBadie Jvan den Bogaard BZverev IMcCarthy AMir ASGareth ABroadhurst PCubero PJCowton ASantanilla JNunes SKohler KRipolles-Melchor JBarrueco-Francioni JEHaque IUAl Qudah BMTaborda LPurvis SMirabella LSokolov DFrenzel TSierra RQMorais RMesland JBGervin KKent MBinnie AGotz VNNielsen NDESICM UNITE COVID investigatorsAlkhalaf Avan Bussel BFrutos-Vivar FSaracoglu KTFraga XTVanhove PVargas PAbusalama ABintaher ASuner AOAchterberg SMontrucchio GValero CMSaif IACochrane AAlghnam MGlotta ADuric NSaha RBoada PRNKesecioglu JFicial BHamid TDendane TJayyab MAAleef MCosta VTonetti TVladislav BPadilla-Serrano ASzakmany TAcosta GPMichael SChrisment ATuran IODavey MJawa RAzzam ARobin NTharwat ADe Grooth HJRodriguez-Solis CKilsand KPeris FSpadaro SShlyk ITharwat SMarkou NDel Pilar Garcia-Bonillo MSalaverria IHussein AMAkbas TRosenberger DErcole AGuzzardella APoulton LCharron MHumaid FBBaiou AKansal ALeganes NCSingatullina NBota MGira AAl Maslamani MGraham SSuner KOAwad AKCagova LHenning JCuadrado MMGroeneveld MVenkatesh HBoulanger CKranen HPaleari COrtiz ABde Pablo Sanchez REkren PKCudia ACosar AWentowski CFranco DMEller PNichol AGavrilova EOmrani AMehagnoul-Schipper JIoan AMCampbell ZSalciute-Simene EGhozy SNg JBonell-Goytisolo JMMyatra SNRoriz CVijayakumar GTruman NHarding DBrun JLBJimenez Jde Cabo CMGrecu IVan Malderen CLorenz MChavez AEElmandouh OPoliakov IKumar ABeishuizen ABлacoвa MfalseCo-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set.<h4>Background</h4>The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.<h4>Methods</h4>This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020)2022-01-01T00:00:00Z2022 Aug2026-06-01T02:18:41.558Z2025-04-06T16:13:02.28ZS-EPMC93471633592286010.1186/s13054-022-04108-8