biostudies-literatureUnknown127(8)Bicchetti MUniversità degli Studi di Roma La Sapienza<h4>Purpose</h4>To determine the clinical, pathological, and radiological features, including the Vesical Imaging-Reporting and Data System (VI-RADS) score, independently correlating with muscle-invasive bladder cancer (BCa), in a multicentric national setting.<h4>Method and materials</h4>Patients with BCa suspicion were offered magnetic resonance imaging (MRI) before trans-urethral resection of bladder tumor (TURBT). According to VI-RADS, a cutoff of ≥ 3 or ≥ 4 was assumed to define muscle-invasive bladder cancer (MIBC). Trans-urethral resection of the tumor (TURBT) and/or cystectomy reports were compared with preoperative VI-RADS scores to assess accuracy of MRI for discriminating between non-muscle-invasive versus MIBC. Performance was assessed by ROC curve analysis. Two univariable andLa Radiologia medica881-890https://www.ebi.ac.uk/biostudies/studies/S-EPMC9349064biostudies-literatureA novel pathway to detect muscle-invasive bladder cancer based on integrated clinical features and VI-RADS score on MRI: results of a prospective multicenter study.PMC9349064Schiavina RPanebianco VBriganti ABrunocilla EDe Cobelli FFlammia SCatalano CGirometti RCardone GBicchetti MSimone GPecoraro MLeonardo CGiannarini GGaudiano CDel Giudice FfalseA novel pathway to detect muscle-invasive bladder cancer based on integrated clinical features and VI-RADS score on MRI: results of a prospective multicenter study.<h4>Purpose</h4>To determine the clinical, pathological, and radiological features, including the Vesical Imaging-Reporting and Data System (VI-RADS) score, independently correlating with muscle-invasive bladder cancer (BCa), in a multicentric national setting.<h4>Method and materials</h4>Patients with BCa suspicion were offered magnetic resonance imaging (MRI) before trans-urethral resection of bladder tumor (TURBT). According to VI-RADS, a cutoff of ≥ 3 or ≥ 4 was assumed to define muscle-invasive bladder cancer (MIBC). Trans-urethral resection of the tumor (TURBT) and/or cystectomy reports were compared with preoperative VI-RADS scores to assess accuracy of MRI for discriminating between non-muscle-invasive versus MIBC. Performance was assessed by ROC curve analysis. Two univariable and2022-01-01T00:00:00Z2022 Aug2025-04-04T22:36:35.864Z2025-04-04T22:36:35.864ZS-EPMC93490643576325110.1007/s11547-022-01513-5