biostudies-literatureUnknown158(9)Trefzer L<h4>Importance</h4>Kidney-urinary tract (KUT) manifestations cause substantial morbidity in patients with junctional epidermolysis bullosa (JEB), but the spectrum of disease severity and the clinical course have been poorly characterized.<h4>Objective</h4>To examine in a large cohort of patients with intermediate JEB the KUT manifestations, diagnostic and therapeutic procedures, genotype-phenotype correlations, and outcomes as a basis for recommendations, prognosis, and management.<h4>Design, setting, and participants</h4>In this retrospective, longitudinal case series study, 99 patients with a diagnosis of JEB based on clinical and genetic findings who were treated in a single dermatology department in Freiburg, Germany, were assessed during an 18-year period (January 1, 2003, to DecemberJAMA dermatology1057-1062https://www.ebi.ac.uk/biostudies/studies/S-EPMC9350844biostudies-literatureKidney-Urinary Tract Involvement in Intermediate Junctional Epidermolysis Bullosa.PMC9350844Trefzer LPohl MNystrom AMiernik AHas CSchwieger-Briel AConradt GfalseKidney-Urinary Tract Involvement in Intermediate Junctional Epidermolysis Bullosa.<h4>Importance</h4>Kidney-urinary tract (KUT) manifestations cause substantial morbidity in patients with junctional epidermolysis bullosa (JEB), but the spectrum of disease severity and the clinical course have been poorly characterized.<h4>Objective</h4>To examine in a large cohort of patients with intermediate JEB the KUT manifestations, diagnostic and therapeutic procedures, genotype-phenotype correlations, and outcomes as a basis for recommendations, prognosis, and management.<h4>Design, setting, and participants</h4>In this retrospective, longitudinal case series study, 99 patients with a diagnosis of JEB based on clinical and genetic findings who were treated in a single dermatology department in Freiburg, Germany, were assessed during an 18-year period (January 1, 2003, to December2022-01-01T00:00:00Z2022 Sep2026-05-09T14:02:12.958Z2025-04-07T04:16:14.644ZS-EPMC93508443592109110.1001/jamadermatol.2022.2885