{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhou Y"],"pubmed_abstract":["Cutaneous melanoma (CM) is an aggressive form of malignancy with poor prognostic value. Cuproptosis is a novel type of cell death regulatory mechanism in tumors. However, the role of cuproptosis-related long noncoding RNAs (lncRNAs) in CM remains elusive. The cuproptosis-related lncRNAs were identified using the Pearson correlation algorithm. Through the univariate and multivariate Cox regression analysis, the prognosis of seven lncRNAs associated with cuproptosis was established and a new risk model was constructed. ESTIMATE, CIBERSORT, and single sample gene set enrichment analyses (ssGSEA) were applied to evaluate the immune microenvironment landscape. The Kaplan-Meier survival analysis revealed that the overall survival (OS) of CM patients in the high-risk group was remarkably lower th"],"journal":["Frontiers in genetics"],"pagination":["959456"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9354044"],"repository":["biostudies-literature"],"pubmed_title":["A novel risk model based on cuproptosis-related lncRNAs predicted prognosis and indicated immune microenvironment landscape of patients with cutaneous melanoma."],"pmcid":["PMC9354044"],"pubmed_authors":["Shu Q","Li J","Wang C","Fu Z","Xie M","Gu J","Chen Y","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"A novel risk model based on cuproptosis-related lncRNAs predicted prognosis and indicated immune microenvironment landscape of patients with cutaneous melanoma.","description":"Cutaneous melanoma (CM) is an aggressive form of malignancy with poor prognostic value. Cuproptosis is a novel type of cell death regulatory mechanism in tumors. However, the role of cuproptosis-related long noncoding RNAs (lncRNAs) in CM remains elusive. The cuproptosis-related lncRNAs were identified using the Pearson correlation algorithm. Through the univariate and multivariate Cox regression analysis, the prognosis of seven lncRNAs associated with cuproptosis was established and a new risk model was constructed. ESTIMATE, CIBERSORT, and single sample gene set enrichment analyses (ssGSEA) were applied to evaluate the immune microenvironment landscape. The Kaplan-Meier survival analysis revealed that the overall survival (OS) of CM patients in the high-risk group was remarkably lower th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T15:59:17.385Z","creation":"2025-02-19T04:54:04.299Z"},"accession":"S-EPMC9354044","cross_references":{"pubmed":["35938036"],"doi":["10.3389/fgene.2022.959456"]}}