{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Du B"],"funding":["Health Commission of Hubei Province","Natural Science Foundation of Hubei Province"],"pubmed_abstract":["Upon activation by the pathogen through T-cell receptors (TCRs), γδT cells suppress the pathogenic replication and thus play important roles against viral infections. Targeting SARS-CoV-2 <i>via</i> γδT cells provides alternative therapeutic strategies. However, little is known about the recognition of SARS-CoV-2 antigens by γδT cells. We discovered a specific Vγ9/δ2 CDR3 by analyzing γδT cells derived from the patients infected by SARS-CoV-2. Using a cell model exogenously expressing γδ-TCR established, we further screened the structural motifs within the CDR3 responsible for binding to γδ-TCR. Importantly, these sequences were mapped to NSP8, a non-structural protein in SARS-CoV-2. Our results suggest that NSP8 mediates the recognition by γδT cells and thus could serve as a potential tar"],"journal":["Frontiers in microbiology"],"pagination":["936272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9354780"],"repository":["biostudies-literature"],"pubmed_title":["Non-structure protein ORF1ab (NSP8) in SARS-CoV-2 contains potential γδT cell epitopes."],"pmcid":["PMC9354780"],"pubmed_authors":["Li G","Xi X","Du B","Guo Y","Zhu Y","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Non-structure protein ORF1ab (NSP8) in SARS-CoV-2 contains potential γδT cell epitopes.","description":"Upon activation by the pathogen through T-cell receptors (TCRs), γδT cells suppress the pathogenic replication and thus play important roles against viral infections. Targeting SARS-CoV-2 <i>via</i> γδT cells provides alternative therapeutic strategies. However, little is known about the recognition of SARS-CoV-2 antigens by γδT cells. We discovered a specific Vγ9/δ2 CDR3 by analyzing γδT cells derived from the patients infected by SARS-CoV-2. Using a cell model exogenously expressing γδ-TCR established, we further screened the structural motifs within the CDR3 responsible for binding to γδ-TCR. Importantly, these sequences were mapped to NSP8, a non-structural protein in SARS-CoV-2. Our results suggest that NSP8 mediates the recognition by γδT cells and thus could serve as a potential tar","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T13:07:40.435Z","creation":"2025-04-06T14:07:23.547Z"},"accession":"S-EPMC9354780","cross_references":{"pubmed":["35935236"],"doi":["10.3389/fmicb.2022.936272"]}}