{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Faraji J"],"pubmed_abstract":["Important factors influencing the outcome of animal experiments in preclinical research are often overlooked. In the current study, the reaction of female and male rats toward the biological sex of a human experimenter was investigated in terms of anxiety-like behaviors and physiological stress responses, as measured by infrared (IR) thermography, circulating corticosterone (CORT) and oxytocin levels. Female rats displayed consistently exacerbated anxiety-related behaviors along with elevated body surface temperature during repeated exposure to male experimenters. Experimental stress further intensified thermal responses to a male experimenter, especially in female rats. The behavioral responses to a male experimenter in females were associated with higher circulating CORT and lower oxytoc"],"journal":["Frontiers in neuroscience"],"pagination":["965500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9354940"],"repository":["biostudies-literature"],"pubmed_title":["Sex-specific stress and biobehavioral responses to human experimenters in rats."],"pmcid":["PMC9354940"],"pubmed_authors":["Ambeskovic M","Whitten K","Toly J","Lopes NA","Faraji J","Olson DM","Sauter N","Metz GAS"],"additional_accession":[]},"is_claimable":false,"name":"Sex-specific stress and biobehavioral responses to human experimenters in rats.","description":"Important factors influencing the outcome of animal experiments in preclinical research are often overlooked. In the current study, the reaction of female and male rats toward the biological sex of a human experimenter was investigated in terms of anxiety-like behaviors and physiological stress responses, as measured by infrared (IR) thermography, circulating corticosterone (CORT) and oxytocin levels. Female rats displayed consistently exacerbated anxiety-related behaviors along with elevated body surface temperature during repeated exposure to male experimenters. Experimental stress further intensified thermal responses to a male experimenter, especially in female rats. The behavioral responses to a male experimenter in females were associated with higher circulating CORT and lower oxytoc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T14:16:26.868Z","creation":"2025-02-19T05:05:38.906Z"},"accession":"S-EPMC9354940","cross_references":{"pubmed":["35937894"],"doi":["10.3389/fnins.2022.965500"]}}