{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Liang Q"],"pubmed_abstract":["<i>Listeria monocytogenes</i> (LM) induces efficient and specific T-cell immune responses in the host. Listeriolysin O (LLO) is the main virulence protein of LM. LLO helps LM escape from the lysosome. However, the pronounced pathogenicity of LM limits its practical application as a live bacterial vector. <i>Listeria ivanovii</i> (LI) also displays intracellular parasitic abilities, cell to cell transfer, and other LM properties, with an elevated biosafety relative to LM. We have confirmed that LI can be used as a viable bacterial vaccine vector. However, we have also observed <i>in vivo</i> that LI vector vaccine candidates survive in the immune organ (spleen) for a shorter time compared with the survival time of LM and elicit weaker immune responses compared with LM. Studies have confirme"],"journal":["Frontiers in microbiology"],"pagination":["962326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9355162"],"repository":["biostudies-literature"],"pubmed_title":["Recombinant <i>Listeria ivanovii</i> strain expressing listeriolysin O in place of ivanolysin O might be a potential antigen carrier for vaccine construction."],"pmcid":["PMC9355162"],"pubmed_authors":["Ou Q","Chen Z","Zhang Y","Wang C","Tian S","Li R","Liu S","Liang Q"],"additional_accession":[]},"is_claimable":false,"name":"Recombinant <i>Listeria ivanovii</i> strain expressing listeriolysin O in place of ivanolysin O might be a potential antigen carrier for vaccine construction.","description":"<i>Listeria monocytogenes</i> (LM) induces efficient and specific T-cell immune responses in the host. Listeriolysin O (LLO) is the main virulence protein of LM. LLO helps LM escape from the lysosome. However, the pronounced pathogenicity of LM limits its practical application as a live bacterial vector. <i>Listeria ivanovii</i> (LI) also displays intracellular parasitic abilities, cell to cell transfer, and other LM properties, with an elevated biosafety relative to LM. We have confirmed that LI can be used as a viable bacterial vaccine vector. However, we have also observed <i>in vivo</i> that LI vector vaccine candidates survive in the immune organ (spleen) for a shorter time compared with the survival time of LM and elicit weaker immune responses compared with LM. Studies have confirme","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T14:15:36.502Z","creation":"2025-02-19T05:05:32.549Z"},"accession":"S-EPMC9355162","cross_references":{"pubmed":["35935244"],"doi":["10.3389/fmicb.2022.962326"]}}