{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Yang YS"],"funding":["Beijing Municipal Natural Science Foundation","National Natural Science Foundation of China"],"pubmed_abstract":["<h4>Background</h4>Allergic respiratory diseases have increased dramatically due to air pollution over the past few decades. However, studies are limited on the effects of inorganic components and particulate matter with different particle sizes in smog on allergic diseases, and the possible molecular mechanism of inducing allergies has not been thoroughly studied.<h4>Methods</h4>Four common mineral elements with different particle sizes in smog particles were selected, including Al<sub>2</sub>O<sub>3</sub>, TiO<sub>2</sub>, Fe<sub>2</sub>O<sub>3</sub>, and SiO<sub>2</sub>. We studied the relationship and molecular mechanism of smog particle composition, particle size, and allergic reactions using mast cells, immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis (PCA) model, and an"],"journal":["Frontiers in immunology"],"pagination":["911300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9355306"],"repository":["biostudies-literature"],"pubmed_title":["Nano-silica particles synergistically IgE-mediated mast cell activation exacerbating allergic inflammation in mice."],"pmcid":["PMC9355306"],"pubmed_authors":["Zou Y","Sun JL","Wang A","Wei JF","Ma LL","Shao Y","Luo M","Yang YS","Cao MD","Liu QM","Zhu DX","Xu DD"],"additional_accession":[]},"is_claimable":false,"name":"Nano-silica particles synergistically IgE-mediated mast cell activation exacerbating allergic inflammation in mice.","description":"<h4>Background</h4>Allergic respiratory diseases have increased dramatically due to air pollution over the past few decades. However, studies are limited on the effects of inorganic components and particulate matter with different particle sizes in smog on allergic diseases, and the possible molecular mechanism of inducing allergies has not been thoroughly studied.<h4>Methods</h4>Four common mineral elements with different particle sizes in smog particles were selected, including Al<sub>2</sub>O<sub>3</sub>, TiO<sub>2</sub>, Fe<sub>2</sub>O<sub>3</sub>, and SiO<sub>2</sub>. We studied the relationship and molecular mechanism of smog particle composition, particle size, and allergic reactions using mast cells, immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis (PCA) model, and an","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T23:36:19.783Z","creation":"2025-04-06T09:25:35.378Z"},"accession":"S-EPMC9355306","cross_references":{"pubmed":["35936002"],"doi":["10.3389/fimmu.2022.911300"]}}