{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fleckenstein JM"],"funding":["BLRD VA","NIAID NIH HHS","National Institutes of Health","U.S. Department of Veterans Affairs"],"pagination":["709907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9355458"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2"],"pubmed_abstract":["The enterotoxigenic <i>Escherichia coli</i> (ETEC) are a diverse and genetically plastic pathologic variant (pathovar) of <i>E. coli</i> defined by their production of heat-labile (LT) and heat-stable (ST) enterotoxins. These pathogens, which came to recognition more than four decades ago in patients presenting with severe cholera-like diarrhea, are now known to cause hundreds of millions of cases of symptomatic infection annually. Children in low-middle income regions of the world lacking access to clean water and basic sanitation are disproportionately affected by ETEC. In addition to acute diarrheal morbidity, these pathogens remain a significant cause of mortality in children under the age of five years and have also been linked repeatedly to sequelae of childhood malnutrition and grow"],"journal":["Frontiers in tropical diseases"],"pubmed_title":["Confronting challenges to enterotoxigenic <i>Escherichia coli</i> vaccine development."],"pmcid":["PMC9355458"],"funding_grant_id":["R01 AI089894","R01 AI126887","I01 BX004825"],"pubmed_authors":["Fleckenstein JM"],"additional_accession":[]},"is_claimable":false,"name":"Confronting challenges to enterotoxigenic <i>Escherichia coli</i> vaccine development.","description":"The enterotoxigenic <i>Escherichia coli</i> (ETEC) are a diverse and genetically plastic pathologic variant (pathovar) of <i>E. coli</i> defined by their production of heat-labile (LT) and heat-stable (ST) enterotoxins. These pathogens, which came to recognition more than four decades ago in patients presenting with severe cholera-like diarrhea, are now known to cause hundreds of millions of cases of symptomatic infection annually. Children in low-middle income regions of the world lacking access to clean water and basic sanitation are disproportionately affected by ETEC. In addition to acute diarrheal morbidity, these pathogens remain a significant cause of mortality in children under the age of five years and have also been linked repeatedly to sequelae of childhood malnutrition and grow","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-22T09:52:43.435Z","creation":"2025-04-05T23:16:08.428Z"},"accession":"S-EPMC9355458","cross_references":{"pubmed":["35937717"],"doi":["10.3389/fitd.2021.709907"]}}