{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim M"],"funding":["BLRD VA","National Cancer Institute","NCI NIH HHS","National Institutes of Health","U.S. Department of Veterans Affairs","NIGMS NIH HHS"],"pagination":["1284-1294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9356980"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(8)"],"pubmed_abstract":["Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non-small cell lung cancer tumors and directly activates the NF-κB pathway. In this study, the role of C9b in activation of the NF-κB pathway in vivo, lung inflammation and immune responses, and lung tumorigenesis were examined. Specifically, a transgenic mouse model expressing human C9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive myeloid-derived suppressor cells in contrast to wild-type mice. C9b mice presented with facial dermatitis, a thickened and disorganized de"],"journal":["Molecular cancer research : MCR"],"pubmed_title":["Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis."],"pmcid":["PMC9356980"],"funding_grant_id":["BX001792","CA248298","I01 BX001792","R01 GM137578","R37 CA248298","IK6 BX004603","GM137578","IK6BX004603"],"pubmed_authors":["Kim S","Uram-Tuculescu C","Pillappa R","Chalfant CE","Vu NT","Wang MH","Wang X","Bulut GB","Kim M"],"additional_accession":[]},"is_claimable":false,"name":"Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis.","description":"Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non-small cell lung cancer tumors and directly activates the NF-κB pathway. In this study, the role of C9b in activation of the NF-κB pathway in vivo, lung inflammation and immune responses, and lung tumorigenesis were examined. Specifically, a transgenic mouse model expressing human C9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive myeloid-derived suppressor cells in contrast to wild-type mice. C9b mice presented with facial dermatitis, a thickened and disorganized de","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-03-27T16:27:01.759Z","creation":"2025-08-30T03:05:29.008Z"},"accession":"S-EPMC9356980","cross_references":{"pubmed":["35412615"],"doi":["10.1158/1541-7786.MCR-21-0905"]}}