biostudies-literatureUnknown13Debus JL<h4>Background</h4>Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are vulnerable to the presence of potential drug-drug interactions (pDDIs) and potential drug-food interactions (pDFIs) as they take numerous medications to treat MS, associated symptoms and comorbidities. Knowledge about pDDIs and pDFIs can increase treatment success and reduce side effects.<h4>Objective</h4>We aimed at determining the frequency and severity of pDDIs and pDFIs in PwMS, with regard to polypharmacy.<h4>Methods</h4>In the cross-sectional study, we analysed pDDIs and pDFIs of 627 PwMS aged ⩾18 years. Data collection was performed through patient record reviews, clinical examinations and structured patient interviews. pDDIs and pDFIs weTherapeutic advances in chronic disease20406223221108391https://www.ebi.ac.uk/biostudies/studies/S-EPMC9358348biostudies-literatureAssociated factors of potential drug-drug interactions and drug-food interactions in patients with multiple sclerosis.PMC9358348Zettl UKHecker MBaldt JDebus JLLanghorst SEStreckenbach BMashhadiakbar PBachmann PFrahm NHeidler FfalseAssociated factors of potential drug-drug interactions and drug-food interactions in patients with multiple sclerosis.<h4>Background</h4>Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are vulnerable to the presence of potential drug-drug interactions (pDDIs) and potential drug-food interactions (pDFIs) as they take numerous medications to treat MS, associated symptoms and comorbidities. Knowledge about pDDIs and pDFIs can increase treatment success and reduce side effects.<h4>Objective</h4>We aimed at determining the frequency and severity of pDDIs and pDFIs in PwMS, with regard to polypharmacy.<h4>Methods</h4>In the cross-sectional study, we analysed pDDIs and pDFIs of 627 PwMS aged ⩾18 years. Data collection was performed through patient record reviews, clinical examinations and structured patient interviews. pDDIs and pDFIs we2022-01-01T00:00:00Z20222025-04-04T19:27:35.558Z2025-02-19T01:57:06.17ZS-EPMC93583483595950310.1177/20406223221108391