biostudies-literatureUnknown22(1)Yu H<h4>Background</h4>Opioids remain the mainstream therapy for post-surgical pain. The choice of opioids administered by patient-controlled intravenous analgesia (PCIA) for thoracoscopic lung surgery is unclear. This study compared 3 opioid analgesics for achieving satisfactory analgesia with minimal emesis (SAME).<h4>Methods</h4>This randomized clinical trial enrolled patients scheduled for thoracoscopic lung surgery randomized to receive 1 of 3 opioids for PCIA: oxycodone (group O), hydromorphone (group H), and sufentanil (group S). The primary outcome was the proportion of subjects achieving SAME, i.e., no-to-mild pain (pain score < 4/10) with minimal nausea/vomiting (PONV score < 2/4) when coughing during the pulmonary rehabilitation exercise in the first 3 postoperative days.<h4>ResultsBMC anesthesiology253https://www.ebi.ac.uk/biostudies/studies/S-EPMC9358799biostudies-literaturePatient-controlled intravenous analgesia with opioids after thoracoscopic lung surgery: a randomized clinical trial.PMC9358799Tian WMao WJiang RChen YYu HXu ZJin LfalsePatient-controlled intravenous analgesia with opioids after thoracoscopic lung surgery: a randomized clinical trial.<h4>Background</h4>Opioids remain the mainstream therapy for post-surgical pain. The choice of opioids administered by patient-controlled intravenous analgesia (PCIA) for thoracoscopic lung surgery is unclear. This study compared 3 opioid analgesics for achieving satisfactory analgesia with minimal emesis (SAME).<h4>Methods</h4>This randomized clinical trial enrolled patients scheduled for thoracoscopic lung surgery randomized to receive 1 of 3 opioids for PCIA: oxycodone (group O), hydromorphone (group H), and sufentanil (group S). The primary outcome was the proportion of subjects achieving SAME, i.e., no-to-mild pain (pain score < 4/10) with minimal nausea/vomiting (PONV score < 2/4) when coughing during the pulmonary rehabilitation exercise in the first 3 postoperative days.<h4>Results2022-01-01T00:00:00Z2022 Aug2025-04-04T08:44:58.905Z2025-04-04T08:44:58.905ZS-EPMC93587993594153610.1186/s12871-022-01785-4