biostudies-literatureKim THNCI NIH HHSNational Institutes of HealthNIH HHS3717-3728https://www.ebi.ac.uk/biostudies/studies/S-EPMC9358967biostudies-literatureUnknown46(8)<h4>Purpose</h4>To perform a systematic review and meta-analysis using individual patient data to investigate the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) Treatment Response (TR) algorithm for detecting incomplete necrosis on pathology.<h4>Methods</h4>PubMed and EMBASE were searched from Jan 1, 2017 until October 14, 2020. Studies reporting diagnostic accuracy of LI-RADS TR algorithm on CT or MRI for detecting incomplete necrosis on pathology as a reference standard were included. Sensitivity and specificity were pooled using random-effects model. Subgroup analyses were performed for locoregional treatment (LRT) type and imaging modality.<h4>Results</h4>Six studies (393 patients, 534 lesions) were included. Pooled sensitivity was 0.56 (95% confidence inteAbdominal radiology (New York)LI-RADS treatment response algorithm for detecting incomplete necrosis in hepatocellular carcinoma after locoregional treatment: a systematic review and meta-analysis using individual patient data.PMC9358967Cancer Center Support Grant P30 CA008748P30 CA008748Kim THBurke LMBMendiratta-Lala MWoo SJoo IPark MSDo RKGBashir MRfalseLI-RADS treatment response algorithm for detecting incomplete necrosis in hepatocellular carcinoma after locoregional treatment: a systematic review and meta-analysis using individual patient data.<h4>Purpose</h4>To perform a systematic review and meta-analysis using individual patient data to investigate the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) Treatment Response (TR) algorithm for detecting incomplete necrosis on pathology.<h4>Methods</h4>PubMed and EMBASE were searched from Jan 1, 2017 until October 14, 2020. Studies reporting diagnostic accuracy of LI-RADS TR algorithm on CT or MRI for detecting incomplete necrosis on pathology as a reference standard were included. Sensitivity and specificity were pooled using random-effects model. Subgroup analyses were performed for locoregional treatment (LRT) type and imaging modality.<h4>Results</h4>Six studies (393 patients, 534 lesions) were included. Pooled sensitivity was 0.56 (95% confidence inte2021-01-01T00:00:00Z2021 Aug2025-04-04T10:44:42.463Z2025-04-04T10:44:42.463ZS-EPMC93589673402756610.1007/s00261-021-03122-8