{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["60(1)"],"submitter":["Yang YF"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["<h4>Context</h4>Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly.<h4>Objective</h4>To explore the mechanism of YQCM decoction in the treatment of ARHL.<h4>Materials and methods</h4>The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an <i>in vitro</i> model of ARHL by exposing auditory cells with 100 μM H<sub>2</sub>O<sub>2</sub> for 3 h were applied. Cell viability and mitochondrial membrane potentia"],"journal":["Pharmaceutical biology"],"pagination":["1478-1490"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9359200"],"repository":["biostudies-literature"],"pubmed_title":["Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss."],"pmcid":["PMC9359200"],"pubmed_authors":["Yang YF","Dong Y","Wu RX","Shi JR","Liu Q","Yan XR","Chu M","Fu SP","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.","description":"<h4>Context</h4>Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly.<h4>Objective</h4>To explore the mechanism of YQCM decoction in the treatment of ARHL.<h4>Materials and methods</h4>The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an <i>in vitro</i> model of ARHL by exposing auditory cells with 100 μM H<sub>2</sub>O<sub>2</sub> for 3 h were applied. Cell viability and mitochondrial membrane potentia","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T12:10:45.184Z","creation":"2025-04-19T12:10:45.184Z"},"accession":"S-EPMC9359200","cross_references":{"pubmed":["35938504"],"doi":["10.1080/13880209.2022.2101671"]}}