{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Gao C"],"pubmed_abstract":["In this study, we investigated the effects of intestinal alkaline phosphatase (IAP) in controlled intestinal inflammation and alleviated associated insulin resistance (IR). We also explored the possible underlying molecular mechanisms, showed the preventive effect of IAP on IR <i>in vivo</i>, and verified the dephosphorylation of IAP for the inhibition of intestinal inflammation <i>in vitro</i>. Furthermore, we examined the preventive role of IAP in IR induced by a high-fat diet in mice. We found that an IAP + IAP enhancer significantly ameliorated blood glucose, insulin, low-density lipoprotein, gut barrier function, inflammatory markers, and lipopolysaccharide (LPS) in serum. IAP could dephosphorylate LPS and nucleoside triphosphate in a pH-dependent manner <i>in vitro</i>. Firstly, LPS "],"journal":["Frontiers in immunology"],"pagination":["927272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9359302"],"repository":["biostudies-literature"],"pubmed_title":["Intestinal alkaline phosphatase (IAP, IAP Enhancer) attenuates intestinal inflammation and alleviates insulin resistance."],"pmcid":["PMC9359302"],"pubmed_authors":["Li J","Hui M","Hong W","Dong N","Koko MYF","Gao C","Ding M"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal alkaline phosphatase (IAP, IAP Enhancer) attenuates intestinal inflammation and alleviates insulin resistance.","description":"In this study, we investigated the effects of intestinal alkaline phosphatase (IAP) in controlled intestinal inflammation and alleviated associated insulin resistance (IR). We also explored the possible underlying molecular mechanisms, showed the preventive effect of IAP on IR <i>in vivo</i>, and verified the dephosphorylation of IAP for the inhibition of intestinal inflammation <i>in vitro</i>. Furthermore, we examined the preventive role of IAP in IR induced by a high-fat diet in mice. We found that an IAP + IAP enhancer significantly ameliorated blood glucose, insulin, low-density lipoprotein, gut barrier function, inflammatory markers, and lipopolysaccharide (LPS) in serum. IAP could dephosphorylate LPS and nucleoside triphosphate in a pH-dependent manner <i>in vitro</i>. Firstly, LPS ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-09T15:36:10.703Z","creation":"2025-04-06T09:23:28.128Z"},"accession":"S-EPMC9359302","cross_references":{"pubmed":["35958560"],"doi":["10.3389/fimmu.2022.927272"]}}