{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Zia Q"],"funding":["Ministry of Education - Kingdom of Saudi Arabi"],"pubmed_abstract":["Alzheimer's disease (AD) is a neurodegenerative disease and the most prevalent form of dementia. The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of AD. It has been suggested that date palm, a plant rich in phenolic compounds and flavonoids, can provide an alternative treatment to fight memory loss and cognitive dysfunction due to its potent antioxidant activity. Thus, we studied the effect of flavonoids present in date palm on Aβ<sub>1-40</sub> amyloid formation using molecular docking and molecular dynamics simulation. AutoDock. Myricetin was used as a positive control drug. The flavonoids Diosmetin, Luteolin, and Rutin were found to be potent inhibitors of aggregation (docking energies ≤ -8.05 kcal mol<sup>-1</sup>) targeting Aβ<"],"journal":["Frontiers in neuroscience"],"pagination":["915122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9359633"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Date Palm (<i>Phoenix dactylifera</i>) Phytochemicals on Aβ<sub>1-40</sub> Amyloid Formation: An <i>in-silico</i> Analysis."],"pmcid":["PMC9359633"],"pubmed_authors":["Jamal A","Siddiqui S","Zia Q","Alqurashi YE","Almalki SG","Hashmi MA","Bin Dukhyil A","Banawas S","AlAjmi MF","Rehman MT","Aldhafeeri HQ","Owais M","Ibrahim IM","Alsieni M","Ahmed MZ","Alturaiki W"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Date Palm (<i>Phoenix dactylifera</i>) Phytochemicals on Aβ<sub>1-40</sub> Amyloid Formation: An <i>in-silico</i> Analysis.","description":"Alzheimer's disease (AD) is a neurodegenerative disease and the most prevalent form of dementia. The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of AD. It has been suggested that date palm, a plant rich in phenolic compounds and flavonoids, can provide an alternative treatment to fight memory loss and cognitive dysfunction due to its potent antioxidant activity. Thus, we studied the effect of flavonoids present in date palm on Aβ<sub>1-40</sub> amyloid formation using molecular docking and molecular dynamics simulation. AutoDock. Myricetin was used as a positive control drug. The flavonoids Diosmetin, Luteolin, and Rutin were found to be potent inhibitors of aggregation (docking energies ≤ -8.05 kcal mol<sup>-1</sup>) targeting Aβ<","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T04:30:59.47Z","creation":"2024-11-11T23:26:17.042Z"},"accession":"S-EPMC9359633","cross_references":{"pubmed":["35958986"],"doi":["10.3389/fnins.2022.915122"]}}