biostudies-literatureKrauß LDFGDeutsche KrebshilfeWilhelm-Sander-Stiftung695-707https://www.ebi.ac.uk/biostudies/studies/S-EPMC9359718biostudies-literatureUnknown82(4)The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated with metastasis, a multistep process that is incompletely understood in this disease. Although genetic drivers of PDAC metastasis have not been defined, transcriptional and epigenetic rewiring can contribute to the metastatic process. The epigenetic eraser histone deacetylase 2 (HDAC2) has been connected to less differentiated PDAC, but the function of HDAC2 in PDAC has not been comprehensively evaluated. Using genetically defined models, we show that HDAC2 is a cellular fitness factor that controls cell cycle in vitro and metastasis in vivo, particularly in undifferentiated, mesenchymal PDAC cells. Unbiased expression profiling detected a core set of HDAC2-regulated genes. HDAC2 controlled expresCancer researchHDAC2 Facilitates Pancreatic Cancer Metastasis.PMC9359718P12SFB1321P1370113760SFB1321 S01 and S02959/6-12017.048.2701143281112733296284922019.086.1RE 3723/4-1Hastreiter SUrban BCTerrasi AKlement CCernilogar FMde Andrade Kratzig NWenzel PWirth MSchmid RMEngleitner TKramer OHSteiger KHassan ZSchneider GSchneider COllinger RLankes KRad RKrauß LReichert MSchotta GSaur DfalseHDAC2 Facilitates Pancreatic Cancer Metastasis.The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated with metastasis, a multistep process that is incompletely understood in this disease. Although genetic drivers of PDAC metastasis have not been defined, transcriptional and epigenetic rewiring can contribute to the metastatic process. The epigenetic eraser histone deacetylase 2 (HDAC2) has been connected to less differentiated PDAC, but the function of HDAC2 in PDAC has not been comprehensively evaluated. Using genetically defined models, we show that HDAC2 is a cellular fitness factor that controls cell cycle in vitro and metastasis in vivo, particularly in undifferentiated, mesenchymal PDAC cells. Unbiased expression profiling detected a core set of HDAC2-regulated genes. HDAC2 controlled expres2022-01-01T00:00:00Z2022 Feb2026-07-14T21:08:47.677Z2025-04-06T00:53:07.646ZS-EPMC93597183490360610.1158/0008-5472.CAN-20-3209