{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(6)"],"submitter":["Alvarez-Sierra D"],"pubmed_abstract":["<b><i>Background:</i></b> Autoimmune thyroid diseases are the most common types of autoimmune diseases, but their physiopathology is still relatively unexplored. Genotype-tissue expression (GTEx) is a publicly available repository containing RNAseq data, including profiles from thyroid. Approximately 14.8% of these glands were affected by focal lymphocytic thyroiditis and 6.3% were annotated as Hashimoto. We interrogated these data to improve the characterization of infiltrating cells and to identify new molecular pathways active in autoimmune thyroiditis. <b><i>Materials and Methods:</i></b> Histological GTEx images of 336 thyroid samples were classified into three categories, that is, non-infiltrated thyroid, small focal infiltrated thyroid, and extensive lymphoid infiltrated thyroid. Di"],"journal":["Thyroid : official journal of the American Thyroid Association"],"pagination":["682-693"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9360182"],"repository":["biostudies-literature"],"pubmed_title":["Lymphocytic Thyroiditis Transcriptomic Profiles Support the Role of Checkpoint Pathways and B Cells in Pathogenesis."],"pmcid":["PMC9360182"],"pubmed_authors":["Moreno-Llorente P","Iglesias C","Marin-Sanchez A","Gonzalez O","Gomez-Brey A","Caubet E","Zafon C","Petit A","Bello I","Pujol-Borrell R","Alvarez-Sierra D"],"additional_accession":[]},"is_claimable":false,"name":"Lymphocytic Thyroiditis Transcriptomic Profiles Support the Role of Checkpoint Pathways and B Cells in Pathogenesis.","description":"<b><i>Background:</i></b> Autoimmune thyroid diseases are the most common types of autoimmune diseases, but their physiopathology is still relatively unexplored. Genotype-tissue expression (GTEx) is a publicly available repository containing RNAseq data, including profiles from thyroid. Approximately 14.8% of these glands were affected by focal lymphocytic thyroiditis and 6.3% were annotated as Hashimoto. We interrogated these data to improve the characterization of infiltrating cells and to identify new molecular pathways active in autoimmune thyroiditis. <b><i>Materials and Methods:</i></b> Histological GTEx images of 336 thyroid samples were classified into three categories, that is, non-infiltrated thyroid, small focal infiltrated thyroid, and extensive lymphoid infiltrated thyroid. Di","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-28T06:09:06.224Z","creation":"2025-04-04T03:42:50.736Z"},"accession":"S-EPMC9360182","cross_references":{"pubmed":["35403441"],"doi":["10.1089/thy.2021.0694"]}}