{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tian J"],"funding":["Research Project of Anhui Province of China","National Natural Science Foundation of China"],"pagination":["e0010661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9362908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(8)"],"pubmed_abstract":["Schistosomiasis is a serious and widespread parasitic disease caused by infection with Schistosoma. Because the parasite's eggs are primarily responsible for schistosomiasis dissemination and pathogenesis, inhibiting egg production is a potential approach to control the spread and severity of the disease. The bromodomain and extra-terminal (BET) proteins represent promising targets for the development of epigenetic drugs against Schistosoma. JQ-1 is a selective inhibitor of the BET protein family. In the present study, JQ-1 was applied to S. japonicum in vitro. By using laser confocal scanning microscopy and EdU incorporation assays, we showed that application of JQ-1 to worms in vitro affected egg laying and the development of both the male and female reproductive systems. JQ-1 also inhib"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum."],"pmcid":["PMC9362908"],"funding_grant_id":["81271865","KJ2019A0223"],"pubmed_authors":["Tian J","Ding H","Wang P","Shen J","Dai B","Liu M","Gong L","Xia S","Sun W","Ren C"],"additional_accession":[]},"is_claimable":false,"name":"JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum.","description":"Schistosomiasis is a serious and widespread parasitic disease caused by infection with Schistosoma. Because the parasite's eggs are primarily responsible for schistosomiasis dissemination and pathogenesis, inhibiting egg production is a potential approach to control the spread and severity of the disease. The bromodomain and extra-terminal (BET) proteins represent promising targets for the development of epigenetic drugs against Schistosoma. JQ-1 is a selective inhibitor of the BET protein family. In the present study, JQ-1 was applied to S. japonicum in vitro. By using laser confocal scanning microscopy and EdU incorporation assays, we showed that application of JQ-1 to worms in vitro affected egg laying and the development of both the male and female reproductive systems. JQ-1 also inhib","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T22:58:29.955Z","creation":"2025-04-19T22:58:29.955Z"},"accession":"S-EPMC9362908","cross_references":{"pubmed":["35943970"],"doi":["10.1371/journal.pntd.0010661"]}}