{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Meng Z"],"pubmed_abstract":["Targeting mitochondria via nano platform emerged as an attractive anti-tumor pathway due to the central regulation role in cellar apoptosis and drug resistance. Here, a mitochondria-targeting nanoparticle (TOS-PDA-PEG-TPP) was designed to precisely deliver polydopamine (PDA) as the photothermal agent and alpha-tocopherol succinate (α-TOS) as the chemotherapeutic drug to the mitochondria of the tumor cells, which inhibits the tumor growth through chemo- and photothermal- synergistic therapies. TOS-PDA-PEG-TPP was constructed by coating PDA on the surface of TOS NPs self-assembled by α-TOS, followed by grafting PEG and triphenylphosphonium (TPP) on their surface to prolong the blood circulation time and target delivery of TOS and PDA to the mitochondria of tumor cells. <i>In vitro</i> studie"],"journal":["Regenerative biomaterials"],"pagination":["rbac051"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9362997"],"repository":["biostudies-literature"],"pubmed_title":["Mitochondria-targeting polydopamine-coated nanodrugs for effective photothermal- and chemo-synergistic therapies against lung cancer."],"pmcid":["PMC9362997"],"pubmed_authors":["Liu Y","Wang B","Tu P","Liu Q","Xu C","Wan Y","Meng Z","Xu H","Liang R","Shi Y","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondria-targeting polydopamine-coated nanodrugs for effective photothermal- and chemo-synergistic therapies against lung cancer.","description":"Targeting mitochondria via nano platform emerged as an attractive anti-tumor pathway due to the central regulation role in cellar apoptosis and drug resistance. Here, a mitochondria-targeting nanoparticle (TOS-PDA-PEG-TPP) was designed to precisely deliver polydopamine (PDA) as the photothermal agent and alpha-tocopherol succinate (α-TOS) as the chemotherapeutic drug to the mitochondria of the tumor cells, which inhibits the tumor growth through chemo- and photothermal- synergistic therapies. TOS-PDA-PEG-TPP was constructed by coating PDA on the surface of TOS NPs self-assembled by α-TOS, followed by grafting PEG and triphenylphosphonium (TPP) on their surface to prolong the blood circulation time and target delivery of TOS and PDA to the mitochondria of tumor cells. <i>In vitro</i> studie","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T10:44:55.277Z","creation":"2025-04-04T10:44:55.277Z"},"accession":"S-EPMC9362997","cross_references":{"pubmed":["35958515"],"doi":["10.1093/rb/rbac051"]}}