{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(6)"],"submitter":["Buerkli S"],"funding":["Laboratory of Human Nutrition, ETH Zurich","Swiss Federal Institute of Technology Zurich"],"pubmed_abstract":["Objectives
We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH).Methods
We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into ery"],"journal":["European journal of nutrition"],"pagination":["2967-2977"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9363374"],"repository":["biostudies-literature"],"pubmed_title":["The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis."],"pmcid":["PMC9363374"],"pubmed_authors":["Baumgartner J","Zimmermann MB","Koller N","Frey BM","Moretti D","Porto G","Dubach IL","Vallelian F","Zeder C","Teles MJ","Buerkli S","Habermann JH","Salvioni L"],"additional_accession":[]},"is_claimable":false,"name":"The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis.","description":"Objectives
We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH).Methods
We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into ery","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-09T19:29:07.343Z","creation":"2025-02-19T03:23:34.83Z"},"accession":"S-EPMC9363374","cross_references":{"pubmed":["35320401"],"doi":["10.1007/s00394-022-02829-8"]}}