biostudies-literatureUnknown61(6)Buerkli SLaboratory of Human Nutrition, ETH ZurichSwiss Federal Institute of Technology Zurich<h4>Objectives</h4>We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH).<h4>Methods</h4>We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into eryEuropean journal of nutrition2967-2977https://www.ebi.ac.uk/biostudies/studies/S-EPMC9363374biostudies-literatureThe effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis.PMC9363374Baumgartner JZimmermann MBKoller NFrey BMMoretti DPorto GDubach ILVallelian FZeder CTeles MJBuerkli SHabermann JHSalvioni LfalseThe effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis.<h4>Objectives</h4>We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH).<h4>Methods</h4>We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into ery2022-01-01T00:00:00Z2022 Sep2026-05-09T19:29:07.343Z2025-02-19T03:23:34.83ZS-EPMC93633743532040110.1007/s00394-022-02829-8