{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Gould HJ"],"funding":["Louisiana Board of Regents Fellowship for Graduate Training in Integrative Pharmacological Sciences"],"pubmed_abstract":["<h4>Background</h4>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na<sup>+</sup>, K<sup>+</sup>-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.<h4>Methods</h4>Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivabi"],"journal":["Case reports in veterinary medicine"],"pagination":["2747108"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9363929"],"repository":["biostudies-literature"],"pubmed_title":["The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series."],"pmcid":["PMC9363929"],"pubmed_authors":["Gould HJ","Sherman KJ","Hunter RP","Miller PR","Tracey D","Edenfield S","Del Piero F","Melius B","Whitney A","Paul D"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.","description":"<h4>Background</h4>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na<sup>+</sup>, K<sup>+</sup>-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.<h4>Methods</h4>Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivabi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T20:35:30.802Z","creation":"2024-11-20T19:22:09.919Z"},"accession":"S-EPMC9363929","cross_references":{"pubmed":["35967596"],"doi":["10.1155/2022/2747108"]}}