biostudies-literatureUnknown2022Gould HJLouisiana Board of Regents Fellowship for Graduate Training in Integrative Pharmacological Sciences<h4>Background</h4>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na⁺, K⁺-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.<h4>Methods</h4>Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivabiCase reports in veterinary medicine2747108https://www.ebi.ac.uk/biostudies/studies/S-EPMC9363929biostudies-literatureThe Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.PMC9363929Gould HJSherman KJHunter RPMiller PRTracey DEdenfield SDel Piero FMelius BWhitney APaul DfalseThe Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.<h4>Background</h4>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na⁺, K⁺-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.<h4>Methods</h4>Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivabi2022-01-01T00:00:00Z20222025-04-19T20:35:30.802Z2024-11-20T19:22:09.919ZS-EPMC93639293596759610.1155/2022/2747108