{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["328(6)"],"submitter":["RESCUE BT Trial Investigators"],"pubmed_abstract":["<h4>Importance</h4>Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban is effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.<h4>Objective</h4>To assess the efficacy and adverse events of intravenous tirofiban before endovascular thrombectomy for acute ischemic stroke secondary to large vessel occlusion.<h4>Design, setting, and participants</h4>This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 55 hospitals in China, enrolling 948 patients with stroke and proximal intracranial large vessel occlusion presenting within 24 hours "],"journal":["JAMA"],"pagination":["543-553"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9364124"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial."],"pmcid":["PMC9364124"],"pubmed_authors":["Zhang G","Deng S","Xue D","Guo Z","Hu Z","Zhang J","Hu W","Liang Y","Hu X","Zhang M","Wan Y","Hao Y","Shi Z","Zhang S","Ke Y","Yan Z","Su R","Hao Z","Guo J","Guo F","Deng W","Yuan Z","Sang H","Zheng X","RESCUE BT Trial Investigators","Pu J","Xu C","Jin Y","Jin Z","Yuan G","Yuan J","Hu J","Zeng H","Xu X","Zeng F","Zeng G","Lin M","Qi L","Lei L","Cao M","Meng R","Qi J","Fu X","Dai W","Zhao W","Shuai J","Lei B","Tang K","Tang M","Zhao L","Yu T","Li B","Tang T","Wei L","Nogueira RG","Yu Y","Chang M","Zhou P","Ni H","Bai Y","Zhou Y","Zhou X","Zhou Z","Tian Z","Fu D","Peng D","Lv F","Hong Y","Cao W","Yu C","Huang W","Ye S","Cao Z","Huang X","Tian Y","Zhu X","Han J","Han C","Yi D","Kong W","Qin C","Wu J","Huang C","Wu M","Huang J","Ge H","Wu D","Huang L","Wang J","Wang L","Yue C","Saver JL","Qiu Z","Wen H","Wang N","Xie F","Wang S","Wang T","Gu G","Sun D","Wen C","Shang X","Chen X","Chen S","Wang Y","Wu W","Wu Y","Sun J","Wu X","Yang H","Li H","Yang J","Li J","Xie Y","Li C","Li F","Chen L","Li R","Sun Y","Li L","Lu M","Li Z","Yang Y","Zuo J","Du J","Yang Q","Yang S","Long C","Liu J","Jiang L","Luo Z","Jiang S","Liu S","Liu T","Gong Z","Miao J","Liu W","Liu X","Liu Y","Song K","Ding X","Long W","Xu A","Zheng C","Zheng B","Song B","Ju D","Zi W","Song J","Duan Z","Luo J","Pan C","Zhang Z","Zhang Y","Luo W","Yan D","Luo X","Liu C","Luo S","Liu D","Fang L"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial.","description":"<h4>Importance</h4>Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban is effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.<h4>Objective</h4>To assess the efficacy and adverse events of intravenous tirofiban before endovascular thrombectomy for acute ischemic stroke secondary to large vessel occlusion.<h4>Design, setting, and participants</h4>This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 55 hospitals in China, enrolling 948 patients with stroke and proximal intracranial large vessel occlusion presenting within 24 hours ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-21T18:12:02.58Z","creation":"2025-04-05T17:07:58.296Z"},"accession":"S-EPMC9364124","cross_references":{"pubmed":["35943471"],"doi":["10.1001/jama.2022.12584"]}}