{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["328(6)"],"submitter":["Sandner S"],"pubmed_abstract":["<h4>Importance</h4>The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear.<h4>Objective</h4>To compare the risks of vein graft failure and bleeding associated with ticagrelor dual antiplatelet therapy (DAPT) or ticagrelor monotherapy vs aspirin among patients undergoing coronary artery bypass graft surgery.<h4>Data sources</h4>MEDLINE, Embase, and Cochrane Library databases from inception to June 1, 2022, without language restriction.<h4>Study selection</h4>Randomized clinical trials (RCTs) comparing the effects of ticagrelor DAPT or ticagrelor monotherapy vs aspirin on saphenous vein graft failure.<h4>Data extraction and synthesis</h4>Individual patient data provided by each trial were synthesized into a combined data set for independent "],"journal":["JAMA"],"pagination":["554-562"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9364127"],"repository":["biostudies-literature"],"pubmed_title":["Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis."],"pmcid":["PMC9364127"],"pubmed_authors":["Audisio K","Zhu Y","Fremes SE","Starovoytov A","Gaudino M","Redfors B","Saw J","Angiolillo DJ","Ten Berg JM","Zhao Q","Peper J","Janssen PWA","Kulik A","Ruel M","Soletti GJ","Sandner S","Willemsen LM","Mehran R"],"additional_accession":[]},"is_claimable":false,"name":"Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis.","description":"<h4>Importance</h4>The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear.<h4>Objective</h4>To compare the risks of vein graft failure and bleeding associated with ticagrelor dual antiplatelet therapy (DAPT) or ticagrelor monotherapy vs aspirin among patients undergoing coronary artery bypass graft surgery.<h4>Data sources</h4>MEDLINE, Embase, and Cochrane Library databases from inception to June 1, 2022, without language restriction.<h4>Study selection</h4>Randomized clinical trials (RCTs) comparing the effects of ticagrelor DAPT or ticagrelor monotherapy vs aspirin on saphenous vein graft failure.<h4>Data extraction and synthesis</h4>Individual patient data provided by each trial were synthesized into a combined data set for independent ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-18T23:28:46.688Z","creation":"2025-04-07T11:03:23.393Z"},"accession":"S-EPMC9364127","cross_references":{"pubmed":["35943473"],"doi":["10.1001/jama.2022.11966"]}}