biostudies-literatureUnknown328(6)Sandner S<h4>Importance</h4>The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear.<h4>Objective</h4>To compare the risks of vein graft failure and bleeding associated with ticagrelor dual antiplatelet therapy (DAPT) or ticagrelor monotherapy vs aspirin among patients undergoing coronary artery bypass graft surgery.<h4>Data sources</h4>MEDLINE, Embase, and Cochrane Library databases from inception to June 1, 2022, without language restriction.<h4>Study selection</h4>Randomized clinical trials (RCTs) comparing the effects of ticagrelor DAPT or ticagrelor monotherapy vs aspirin on saphenous vein graft failure.<h4>Data extraction and synthesis</h4>Individual patient data provided by each trial were synthesized into a combined data set for independent JAMA554-562https://www.ebi.ac.uk/biostudies/studies/S-EPMC9364127biostudies-literatureAssociation of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis.PMC9364127Audisio KZhu YFremes SEStarovoytov AGaudino MRedfors BSaw JAngiolillo DJTen Berg JMZhao QPeper JJanssen PWAKulik ARuel MSoletti GJSandner SWillemsen LMMehran RfalseAssociation of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis.<h4>Importance</h4>The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear.<h4>Objective</h4>To compare the risks of vein graft failure and bleeding associated with ticagrelor dual antiplatelet therapy (DAPT) or ticagrelor monotherapy vs aspirin among patients undergoing coronary artery bypass graft surgery.<h4>Data sources</h4>MEDLINE, Embase, and Cochrane Library databases from inception to June 1, 2022, without language restriction.<h4>Study selection</h4>Randomized clinical trials (RCTs) comparing the effects of ticagrelor DAPT or ticagrelor monotherapy vs aspirin on saphenous vein graft failure.<h4>Data extraction and synthesis</h4>Individual patient data provided by each trial were synthesized into a combined data set for independent 2022-01-01T00:00:00Z2022 Aug2025-04-18T23:28:46.688Z2025-04-07T11:03:23.393ZS-EPMC93641273594347310.1001/jama.2022.11966