biostudies-literatureLevy DTCancer Research UKMedical Research CouncilNational Institute for Health Research (NIHR)Division of Cancer Prevention, National Cancer InstituteNCI NIH HHS1196-1211https://www.ebi.ac.uk/biostudies/studies/S-EPMC9364758biostudies-literatureUnknown116(5)<h4>Background and aims</h4>Whereas the use of nicotine vaping products (NVPs) is widespread, their impact on smoking prevalence is controversial. This study considered the potential impact of NVPs on smoking prevalence in England.<h4>Design</h4>Indirect simulation model. The England SimSmoke model is validated through 2012, before NVP use became more widely used by smokers. Because information on NVP-related transitions is limited, an indirect method is used; the difference in observed smoking prevalence (reflecting NVPs) is compared with a 2012-2019 counterfactual No-NVP scenario (without NVPs) to estimate the impact of NVPs on smoking and smoking-attributable deaths.<h4>Setting</h4>England, 2000-2019.<h4>Participants</h4>Nationally representative sample of population.<h4>Measurements</hAddiction (Abingdon, England)England SimSmoke: the impact of nicotine vaping on smoking prevalence and smoking-attributable deaths in England.PMC9364758P01 CA200512NIHR200262P01CA200512C1417/A14135MR/S037519/122962Jarvis MJLi YTravis NBrown JLevy DTYuan ZMcNeill ASanchez-Romero LMfalseEngland SimSmoke: the impact of nicotine vaping on smoking prevalence and smoking-attributable deaths in England.<h4>Background and aims</h4>Whereas the use of nicotine vaping products (NVPs) is widespread, their impact on smoking prevalence is controversial. This study considered the potential impact of NVPs on smoking prevalence in England.<h4>Design</h4>Indirect simulation model. The England SimSmoke model is validated through 2012, before NVP use became more widely used by smokers. Because information on NVP-related transitions is limited, an indirect method is used; the difference in observed smoking prevalence (reflecting NVPs) is compared with a 2012-2019 counterfactual No-NVP scenario (without NVPs) to estimate the impact of NVPs on smoking and smoking-attributable deaths.<h4>Setting</h4>England, 2000-2019.<h4>Participants</h4>Nationally representative sample of population.<h4>Measurements</h2021-01-01T00:00:00Z2021 May2025-04-18T15:25:39.208Z2025-04-07T02:02:21.136ZS-EPMC93647583294941910.1111/add.15269