biostudies-literatureEid ANIA NIH HHSNIEHS NIH HHSNINDS NIH HHS87005https://www.ebi.ac.uk/biostudies/studies/S-EPMC9364816biostudies-literatureUnknown130(8)<h4>Background</h4>The interaction of aging-related, genetic, and environmental factors is thought to contribute to the etiology of late-onset, sporadic Alzheimer's disease (AD). We previously reported that serum levels of <i>p,p</i>'-dichlorodiphenyldichloroethylene (DDE), a long-lasting metabolite of the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT), were significantly elevated in patients with AD and associated with the risk of AD diagnosis. However, the mechanism by which DDT may contribute to AD pathogenesis is unknown.<h4>Objectives</h4>This study sought to assess effects of DDT exposure on the amyloid pathway in multiple <i>in vitro</i> and <i>in vivo</i> models.<h4>Methods</h4>Cultured cells (SH-SY5Y and primary neurons), transgenic flies overexpressing amyloid betEnvironmental health perspectivesEffects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk.PMC9364816R01 ES026057R13 AG069380R01 ES024288U01 NS108956R01 ES027481P30 ES005022R01 ES021800Mhatre-Winters ILisci MHart RPBennett JWHossain MMRichardson JRCarney KKonsolaki MHan YEdler MKSammoura FMvon Stein REid AfalseEffects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk.<h4>Background</h4>The interaction of aging-related, genetic, and environmental factors is thought to contribute to the etiology of late-onset, sporadic Alzheimer's disease (AD). We previously reported that serum levels of <i>p,p</i>'-dichlorodiphenyldichloroethylene (DDE), a long-lasting metabolite of the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT), were significantly elevated in patients with AD and associated with the risk of AD diagnosis. However, the mechanism by which DDT may contribute to AD pathogenesis is unknown.<h4>Objectives</h4>This study sought to assess effects of DDT exposure on the amyloid pathway in multiple <i>in vitro</i> and <i>in vivo</i> models.<h4>Methods</h4>Cultured cells (SH-SY5Y and primary neurons), transgenic flies overexpressing amyloid bet2022-01-01T00:00:00Z2022 Aug2025-04-04T10:44:37.065Z2025-04-04T10:44:37.065ZS-EPMC93648163594695310.1289/EHP10576