biostudies-literatureNguyen LHStand Up To CancerMassachusetts General HospitalNIDDK NIH HHSPfizerMark and Lisa SchwartzCrohn's and Colitis FoundationNCI NIH HHSZoe GlobalNational Institutes of HealthMassachusetts Consortium on Pathogen ReadinessAmerican Gastroenterological Associatione0271661https://www.ebi.ac.uk/biostudies/studies/S-EPMC9365178biostudies-literatureUnknown17(8)Racial/ethnic minorities have been disproportionately impacted by COVID-19. The effects of COVID-19 on the long-term mental health of minorities remains unclear. To evaluate differences in odds of screening positive for depression and anxiety among various racial and ethnic groups during the latter phase of the COVID-19 pandemic, we performed a cross-sectional analysis of 691,473 participants nested within the prospective smartphone-based COVID Symptom Study in the United States (U.S.) and United Kingdom (U.K). from February 23, 2021 to June 9, 2021. In the U.S. (n=57,187), compared to White participants, the multivariable odds ratios (ORs) for screening positive for depression were 1·16 (95% CI: 1·02 to 1·31) for Black, 1·23 (1·11 to 1·36) for Hispanic, and 1·15 (1·02 to 1·30) for Asian pPloS oneThe mental health burden of racial and ethnic minorities during the COVID-19 pandemic.PMC9365178K01 DK120742COVID-19 Rapid Response Research AwardK23 DK125838P50CA244433Stuart and Suzanne Steele Research ScholarResearch Scholars AwardK23DK125838Career Development Award and Research Fellowship AwardP50 CA244433K01DK120742Thompson EJSudre CHMerino JSteves CJDrew DAMay ASanders ARWarner ETMa WMurray AMKim DYBerry SEGraham MSSpector TDWolf JKoenen KCOurselin SNguyen LHMartinez MEChan ATJoshi ADSelvachandran SKlaser KHu CFigueiredo JCMehta RSAnyane-Yeboa ADavid SPJorgensen SfalseThe mental health burden of racial and ethnic minorities during the COVID-19 pandemic.Racial/ethnic minorities have been disproportionately impacted by COVID-19. The effects of COVID-19 on the long-term mental health of minorities remains unclear. To evaluate differences in odds of screening positive for depression and anxiety among various racial and ethnic groups during the latter phase of the COVID-19 pandemic, we performed a cross-sectional analysis of 691,473 participants nested within the prospective smartphone-based COVID Symptom Study in the United States (U.S.) and United Kingdom (U.K). from February 23, 2021 to June 9, 2021. In the U.S. (n=57,187), compared to White participants, the multivariable odds ratios (ORs) for screening positive for depression were 1·16 (95% CI: 1·02 to 1·31) for Black, 1·23 (1·11 to 1·36) for Hispanic, and 1·15 (1·02 to 1·30) for Asian p2022-01-01T00:00:00Z20222025-04-19T22:56:45.638Z2025-04-19T22:56:45.638ZS-EPMC93651783594754310.1371/journal.pone.0271661