biostudies-literatureAshraf-Uz-Zaman MNational Institute of Neurological Disorders and StrokeSouth Plains FoundationNIMH NIH HHSNational Cancer InstituteNINDS NIH HHSNCI NIH HHSNational Institute of Mental HealthCancer Prevention and Research Institute of Texas217-228https://www.ebi.ac.uk/biostudies/studies/S-EPMC9365315biostudies-literatureUnknown13(2)The dopaminergic system is involved in the regulation of immune responses in various homeostatic and disease conditions. For conditions such as Parkinson's disease and multiple sclerosis (MS), pharmacological modulation of dopamine (DA) system activity is thought to have therapeutic relevance, providing the basis for using dopaminergic agents as a treatment of relevant states. In particular, it was proposed that restoration of DA levels may inhibit neuroinflammation. We have recently reported a new class of dopamine transporter (DAT) inhibitors with high selectivity to the DAT over other G-protein coupled receptors tested. Here, we continue their evaluation as monoamine transporter inhibitors. Furthermore, we show that the urea-like DAT inhibitor (compound <b>5</b>) has statistically signiACS chemical neuroscienceEvaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.PMC9365315NS109255RP210154NS1069021R15CA231339-0R01 NS106902R01 NS109255HHSN-271-2013-00017-CR15 CA231339RP170003R01 NS038261HHSN271201300017CNS038261Shahi SJi GSajib MSMikelis CMNeugebauer VAshraf-Uz-Zaman MGerman NAThakolwiboon STidwell DGriffin ZPan JDas HJunell RTrippier PCBarthels DYin LAvila MfalseEvaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.The dopaminergic system is involved in the regulation of immune responses in various homeostatic and disease conditions. For conditions such as Parkinson's disease and multiple sclerosis (MS), pharmacological modulation of dopamine (DA) system activity is thought to have therapeutic relevance, providing the basis for using dopaminergic agents as a treatment of relevant states. In particular, it was proposed that restoration of DA levels may inhibit neuroinflammation. We have recently reported a new class of dopamine transporter (DAT) inhibitors with high selectivity to the DAT over other G-protein coupled receptors tested. Here, we continue their evaluation as monoamine transporter inhibitors. Furthermore, we show that the urea-like DAT inhibitor (compound <b>5</b>) has statistically signi2022-01-01T00:00:00Z2022 Jan2025-04-19T22:58:13.206Z2024-11-14T18:20:05.736ZS-EPMC93653153497817410.1021/acschemneuro.1c00647