{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dylgjeri E"],"funding":["Cancer Research UK","HHS | NIH | National Cancer Institute","NCI NIH HHS","Prostate Cancer Foundation"],"pagination":["1446-1459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9365345"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["<h4>Purpose</h4>DNA-dependent protein kinase catalytic subunit (DNA-PKcs, herein referred as DNA-PK) is a multifunctional kinase of high cancer relevance. DNA-PK is deregulated in multiple tumor types, including prostate cancer, and is associated with poor outcomes. DNA-PK was previously nominated as a therapeutic target and DNA-PK inhibitors are currently undergoing clinical investigation. Although DNA-PK is well studied in DNA repair and transcriptional regulation, much remains to be understood about the way by which DNA-PK drives aggressive disease phenotypes.<h4>Experimental design</h4>Here, unbiased proteomic and metabolomic approaches in clinically relevant tumor models uncovered a novel role of DNA-PK in metabolic regulation of cancer progression. DNA-PK regulation of metabolism was"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer."],"pmcid":["PMC9365345"],"funding_grant_id":["20411","5R01CA18256905","P30 CA056036","F99CA212225","5R01CA17640105","F99 CA212225"],"pubmed_authors":["Lallas CD","Holst J","McCue PA","Vasilevskaya I","Pang A","Dylgjeri E","Chand S","Butler LM","McNair CM","Shafi AA","Kothari V","Semenova G","Schiewer MJ","Gomella LG","Knudsen KE","Seifert EL","Kelly WK","Guan YF","Carroll JS","Gallagher PT","Goodwin JF","Mandigo AC","McCann JJ","Irani S"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer.","description":"<h4>Purpose</h4>DNA-dependent protein kinase catalytic subunit (DNA-PKcs, herein referred as DNA-PK) is a multifunctional kinase of high cancer relevance. DNA-PK is deregulated in multiple tumor types, including prostate cancer, and is associated with poor outcomes. DNA-PK was previously nominated as a therapeutic target and DNA-PK inhibitors are currently undergoing clinical investigation. Although DNA-PK is well studied in DNA repair and transcriptional regulation, much remains to be understood about the way by which DNA-PK drives aggressive disease phenotypes.<h4>Experimental design</h4>Here, unbiased proteomic and metabolomic approaches in clinically relevant tumor models uncovered a novel role of DNA-PK in metabolic regulation of cancer progression. DNA-PK regulation of metabolism was","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T04:27:49.611Z","creation":"2025-04-05T21:00:08.837Z"},"accession":"S-EPMC9365345","cross_references":{"pubmed":["35078861"],"doi":["10.1158/1078-0432.CCR-21-1846"]}}