biostudies-literatureYuan SResearch Grant of CITIC-XiangyaNational Key Research & Developmental Program of ChinaKey Grant of Prevention and Treatment of Birth Defect from Hunan ProvinceNational Natural Science Foundation of ChinaNational Key Research &amp; Developmental Program of ChinaHunan Provincial Grant for Innovative Province Construction1683-1689https://www.ebi.ac.uk/biostudies/studies/S-EPMC9365907biostudies-literatureUnknown39(7)<h4>Purpose</h4>To evaluate the cytogenetic risk of assisted reproductive technology (ART) by comparing the incidence of de novo chromosomal abnormalities between fetuses conceived via in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and natural conception.<h4>Materials and methods</h4>Prenatal invasive diagnostic testing (amniocentesis and cytogenetic analysis) was performed on 1496 fetuses conceived via IVF/ICSI (IVF/ICSI group) and 1396 fetuses from natural conception (NC group). The incidence of de novo chromosomal abnormalities (including aneuploidy and chromosomal structure abnormalities) was used to evaluate the cytogenetic risk of ART. For statistical analysis, χ²-test was used for binary dependent variable. The significance level was P < 0.05 and confiJournal of assisted reproduction and geneticsThe de novo aberration rate of prenatal karyotype was comparable between 1496 fetuses conceived via IVF/ICSI and 1396 fetuses from natural conception.PMC9365907819714472018YFC100490182171608YNXM-202004YNXM-2020062019SK10122019SK4012Gong FYuan SCheng DLi XGuo LLu GHu HTan YQLin GHu LfalseThe de novo aberration rate of prenatal karyotype was comparable between 1496 fetuses conceived via IVF/ICSI and 1396 fetuses from natural conception.<h4>Purpose</h4>To evaluate the cytogenetic risk of assisted reproductive technology (ART) by comparing the incidence of de novo chromosomal abnormalities between fetuses conceived via in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and natural conception.<h4>Materials and methods</h4>Prenatal invasive diagnostic testing (amniocentesis and cytogenetic analysis) was performed on 1496 fetuses conceived via IVF/ICSI (IVF/ICSI group) and 1396 fetuses from natural conception (NC group). The incidence of de novo chromosomal abnormalities (including aneuploidy and chromosomal structure abnormalities) was used to evaluate the cytogenetic risk of ART. For statistical analysis, χ²-test was used for binary dependent variable. The significance level was P < 0.05 and confi2022-01-01T00:00:00Z2022 Jul2025-04-26T07:35:03.754Z2025-04-06T12:23:40.208ZS-EPMC93659073561675610.1007/s10815-022-02500-5