biostudies-literatureAsplund OEuropean Union’s Horizon 2020 Research and Innovation Programme and EFPIASwedish Foundation for Strategic Research to the Lund University Diabetes CentreRegeneron and Eli LillySwiss State Secretariat for Education‚ Research and InnovationDiabetes WellnessInnovative Medicines Initiative 2 Joint UndertakingHeart Lung FoundationCrafoord FoundationSwedish Research CouncilJDRFNovo Nordisk FondenHjelt Foundatione202201376https://www.ebi.ac.uk/biostudies/studies/S-EPMC9366203biostudies-literatureUnknown5(12)Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to create the Islet Gene View (IGW) platform to make this information easily accessible to the scientific community. Expression data were related to islet phenotypes, diabetes status, other islet-expressed genes, islet hormone-encoding genes and for expression in insulin target tissues. The IGW web application produces output graphs for a particular gene of interest. In IGW, 284 differentially expressed genes (DEGs) were identified in T2D donor islets compared with controls. Forty percent of DEGs showed cell-type enrichment and a large proportion sLife science allianceIslet Gene View-a tool to facilitate islet research.PMC9366203NNF18OC003423820180522NNF20OC006348520200891NNF22OC007826716.0097EXODIAB115881NNF17OC0027158720-858-16JDWG2015-2558IRC 15-0067NNF20OC00639162009-10392015-0672231-2008-416Krus UIbrahim HGroop LWierup NArtner IWollheim CHansson OAhlqvist EOtonkoski TMansour-Aly DStorm PHatem GMarchetti PKorsgren OIbberson MOttosson-Laakso ERenstrom ESolimena MMulder HAsplund OChandra VPrasad RBTuomi TfalseIslet Gene View-a tool to facilitate islet research.Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to create the Islet Gene View (IGW) platform to make this information easily accessible to the scientific community. Expression data were related to islet phenotypes, diabetes status, other islet-expressed genes, islet hormone-encoding genes and for expression in insulin target tissues. The IGW web application produces output graphs for a particular gene of interest. In IGW, 284 differentially expressed genes (DEGs) were identified in T2D donor islets compared with controls. Forty percent of DEGs showed cell-type enrichment and a large proportion s2022-01-01T00:00:00Z2022 Aug2026-05-09T19:35:10.175Z2025-04-21T14:51:38.902ZS-EPMC93662033594836710.26508/lsa.202201376