biostudies-literatureTan CSNICHD NIH HHSNIAID NIH HHSNIGMS NIH HHSe2226335https://www.ebi.ac.uk/biostudies/studies/S-EPMC9366542biostudies-literatureUnknown5(8)<h4>Importance</h4>Antibody responses elicited by current messenger RNA (mRNA) COVID-19 vaccines decline rapidly and require repeated boosting.<h4>Objective</h4>To evaluate the immunogenicity and durability of heterologous and homologous prime-boost regimens involving the adenovirus vector vaccine Ad26.COV2.S and the mRNA vaccine BNT162b2.<h4>Design, setting, and participants</h4>In this cohort study at a single clinical site in Boston, Massachusetts, 68 individuals who were vaccinated at least 6 months previously with 2 immunizations of BNT162b2 were boosted with either Ad26.COV2.S or BNT162b2. Enrollment of participants occurred from August 12, 2021, to October 25, 2021, and this study involved 4 months of follow-up. Data analysis was performed from November 2021 to February 2022.<h4>ExpJAMA network openDurability of Heterologous and Homologous COVID-19 Vaccine Boosts.PMC9366542T32 GM144273T32 GM007753K12 HD000849T32 GM008313F30 AI160908R21 AI169309McMahan KLiu JRoy VSchmidt AGYu JHauser BMSadoff JTan CSAlter GJacob-Dolan CMeganck RMRowe MJaegle KHHemond RBarouch DHMunt JEPowers JMLe Gars MMallory MLMattocks MBaric RSHe XBondzie EACollier AYChandrashekar AfalseDurability of Heterologous and Homologous COVID-19 Vaccine Boosts.<h4>Importance</h4>Antibody responses elicited by current messenger RNA (mRNA) COVID-19 vaccines decline rapidly and require repeated boosting.<h4>Objective</h4>To evaluate the immunogenicity and durability of heterologous and homologous prime-boost regimens involving the adenovirus vector vaccine Ad26.COV2.S and the mRNA vaccine BNT162b2.<h4>Design, setting, and participants</h4>In this cohort study at a single clinical site in Boston, Massachusetts, 68 individuals who were vaccinated at least 6 months previously with 2 immunizations of BNT162b2 were boosted with either Ad26.COV2.S or BNT162b2. Enrollment of participants occurred from August 12, 2021, to October 25, 2021, and this study involved 4 months of follow-up. Data analysis was performed from November 2021 to February 2022.<h4>Exp2022-01-01T00:00:00Z2022 Aug2026-06-01T02:21:09.018Z2025-04-19T05:56:37.109ZS-EPMC93665423594738010.1001/jamanetworkopen.2022.26335