biostudies-literatureUnknown16Zou YNational Key Research and Development Program of ChinaAlzheimer's disease (AD) is the sixth leading cause of death worldwide and cannot be effectively cured or prevented; thus, early diagnosis, and intervention are important. The importance of exosomes, membrane-bound extracellular vesicles produced in the endosome of eukaryotic cells, in the development, diagnosis, and treatment of AD has been recognized; however, their specific functions remain controversial and even unclear. With the development of exosome extraction, isolation, and characterization, many studies have focused on exosomes derived from different cells and body fluids. In this study, we summarized the roles of exosomes derived from different body fluids and cells, such as neuron, glial, stem, and endothelial cells, in the development, diagnosis, monitoring, and treatment of AFrontiers in neuroscience936760https://www.ebi.ac.uk/biostudies/studies/S-EPMC9366882biostudies-literatureReview on the roles of specific cell-derived exosomes in Alzheimer's disease.PMC9366882Zou YYu SWang DMu DMa XGao JZhong JQiu LfalseReview on the roles of specific cell-derived exosomes in Alzheimer's disease.Alzheimer's disease (AD) is the sixth leading cause of death worldwide and cannot be effectively cured or prevented; thus, early diagnosis, and intervention are important. The importance of exosomes, membrane-bound extracellular vesicles produced in the endosome of eukaryotic cells, in the development, diagnosis, and treatment of AD has been recognized; however, their specific functions remain controversial and even unclear. With the development of exosome extraction, isolation, and characterization, many studies have focused on exosomes derived from different cells and body fluids. In this study, we summarized the roles of exosomes derived from different body fluids and cells, such as neuron, glial, stem, and endothelial cells, in the development, diagnosis, monitoring, and treatment of A2022-01-01T00:00:00Z20222025-04-04T08:01:15.075Z2025-04-04T08:01:15.075ZS-EPMC93668823596837810.3389/fnins.2022.936760