biostudies-literatureFontvieille EWorld Health Organization877https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367082biostudies-literatureUnknown22(1)<h4>Background</h4>Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.<h4>Methods</h4>We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tBMC cancerInflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study.PMC9367082001Garmendia MLBiessy CRinaldi SBedoya GEcheverri CLin MGCortes BRodriguez ACLoria VDonn TAngel ANavionis ASLazcano MFPorter PLGonzalez POcampo RWirtala KDiaz-Yunez ICock-Rada AGuillen DVial CTorres-Mejia GPorras CFranco LZNavarro EDonato EHernandez APRECAMA teamMoyano LTejeda JHerazo FOssa CAAngeles-Llerenas AJaramillo RArias WHGuenthoer JSanchez GISoto JLCortes YRDiaz LFontvieille EHis MLoucks HRomieu IAlvarado-Cabrero IfalseInflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study.<h4>Background</h4>Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.<h4>Methods</h4>We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the t2022-01-01T00:00:00Z2022 Aug2026-03-27T17:24:35.834Z2024-11-21T09:50:58.429ZS-EPMC93670823594887710.1186/s12885-022-09975-6