{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hering A"],"funding":["European Research Council","Australian Research Council"],"pagination":["9100-9103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(65)"],"pubmed_abstract":["The oxime ligation is a valuable bioorthogonal conjugation reaction but with limited compatibility with disulfide-rich peptides/proteins and time-sensitive applications. Here we overcome these limitations by introducing a strategy that supports regiospecific control, oxidative folding, production of stable aminooxy-precursors for on-demand modification, and complete ligation within 5 min."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides."],"pmcid":["PMC9367247"],"funding_grant_id":["DE150100784, DP190101667, FT210100266","714366"],"pubmed_authors":["Hering A","Muttenthaler M","Braga Emidio N"],"additional_accession":[]},"is_claimable":false,"name":"Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides.","description":"The oxime ligation is a valuable bioorthogonal conjugation reaction but with limited compatibility with disulfide-rich peptides/proteins and time-sensitive applications. Here we overcome these limitations by introducing a strategy that supports regiospecific control, oxidative folding, production of stable aminooxy-precursors for on-demand modification, and complete ligation within 5 min.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-18T18:07:26.22Z","creation":"2025-04-07T05:42:06.371Z"},"accession":"S-EPMC9367247","cross_references":{"pubmed":["35880482"],"doi":["10.1039/d2cc03752a"]}}