biostudies-literatureZhang Rthe Sichuan Province Science and Technology Support ProgramNational Key R&amp;D Program of Chinathe project of health commission of Sichuan provinceClinical Incubation Program of West China Hospital, SCUthe Technology Innovation Project of Chengdu Science and Technology BureauNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaPostdoctoral research and Development Fund and Translational medicine fund of West China Hospitalthe 1·3·5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University3717https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367315biostudies-literatureUnknown14(15)<h4>Background</h4>Vitamin D deficiency is related to increased cancer risk and deaths. However, whether vitamin D supplementation reduces cancer mortality remains unclear, and several randomized controlled trials yield inconsistent results.<h4>Methods</h4>Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched from their inception until 28 June 2022, for randomized controlled trials investigating vitamin D supplementation. Pooled relative risks (RRs) and their 95% confidence intervals (CIs) were estimated. Trials with vitamin D supplementation combined with calcium supplementation versus placebo alone and recruiting participants with cancer at baseline were excluded in the present study.<h4>Results</h4>This study included 12 trials with a total of 72,669 partCancersAssociation between Vitamin D Supplementation and Cancer Mortality: A Systematic Review and Meta-Analysis.PMC93673152021YFSY008, 2020YFS0276, 2020YFS04902021YFE02066002020HXBH119 and CGZH190022019-YF05-00459-SN2018HXFU008816723862018YFA010860419PJ00321HXFH046Peng XXu PFang FHe LYu JZhang RHai YWang JLiu ZChong WHe YZhang YPei YfalseAssociation between Vitamin D Supplementation and Cancer Mortality: A Systematic Review and Meta-Analysis.<h4>Background</h4>Vitamin D deficiency is related to increased cancer risk and deaths. However, whether vitamin D supplementation reduces cancer mortality remains unclear, and several randomized controlled trials yield inconsistent results.<h4>Methods</h4>Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched from their inception until 28 June 2022, for randomized controlled trials investigating vitamin D supplementation. Pooled relative risks (RRs) and their 95% confidence intervals (CIs) were estimated. Trials with vitamin D supplementation combined with calcium supplementation versus placebo alone and recruiting participants with cancer at baseline were excluded in the present study.<h4>Results</h4>This study included 12 trials with a total of 72,669 part2022-01-01T00:00:00Z2022 Jul2025-04-19T22:57:20.774Z2025-02-19T03:32:02.91ZS-EPMC93673153595438110.3390/cancers14153717