{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Persson M"],"funding":["the Swedish state under the agreement between the Swedish government and the country councils, the ALF-agreement","The Sjöberg Foundation","Assar Gabrielsson Foundation","Swedish Cancer Society"],"pagination":["3691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367430"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(15)"],"pubmed_abstract":["Adenoid cystic carcinoma (ACC) is an aggressive head and neck malignancy characterized by a t (6;9) translocation resulting in an <i>MYB-NFIB</i> gene fusion or, more rarely, an <i>MYBL1</i> fusion. The true frequency and clinical significance of these alterations are still unclear. Here, we have used tissue microarrays and analyzed 391 ACCs and 647 non-ACC salivary neoplasms to study the prevalence, expression, and clinical significance of <i>MYB/MYBL1</i> alterations by FISH and immunohistochemistry. Alterations of <i>MYB</i> or <i>MYBL1</i> were found in 78% of the cases, of which 62% had <i>MYB</i> alterations and 16% had <i>MYBL1</i> rearrangements. Overexpression of MYB/MYBL1 oncoproteins was detected in 93% of the cases. <i>MYB</i> split signal, seen in 39% of the cases, was specifi"],"journal":["Cancers"],"pubmed_title":["Rearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study."],"pmcid":["PMC9367430"],"funding_grant_id":["AG-Fond FB17-22, FB20-91","ALFGBG-965537","2021-01-14:4","CAN 21 1773"],"pubmed_authors":["Frierson HF","El-Naggar AK","Loening T","Brandwein-Weber MS","Ferrarotto R","Andersson MK","Stenman G","Mitani Y","Boecker W","Persson M","Moskaluk C","Fonseca I"],"additional_accession":[]},"is_claimable":false,"name":"Rearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study.","description":"Adenoid cystic carcinoma (ACC) is an aggressive head and neck malignancy characterized by a t (6;9) translocation resulting in an <i>MYB-NFIB</i> gene fusion or, more rarely, an <i>MYBL1</i> fusion. The true frequency and clinical significance of these alterations are still unclear. Here, we have used tissue microarrays and analyzed 391 ACCs and 647 non-ACC salivary neoplasms to study the prevalence, expression, and clinical significance of <i>MYB/MYBL1</i> alterations by FISH and immunohistochemistry. Alterations of <i>MYB</i> or <i>MYBL1</i> were found in 78% of the cases, of which 62% had <i>MYB</i> alterations and 16% had <i>MYBL1</i> rearrangements. Overexpression of MYB/MYBL1 oncoproteins was detected in 93% of the cases. <i>MYB</i> split signal, seen in 39% of the cases, was specifi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-22T11:29:46.927Z","creation":"2025-04-06T00:00:34.909Z"},"accession":"S-EPMC9367430","cross_references":{"pubmed":["35954356"],"doi":["10.3390/cancers14153691"]}}