biostudies-literaturePersson Mthe Swedish state under the agreement between the Swedish government and the country councils, the ALF-agreementThe Sjöberg FoundationAssar Gabrielsson FoundationSwedish Cancer Society3691https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367430biostudies-literatureUnknown14(15)Adenoid cystic carcinoma (ACC) is an aggressive head and neck malignancy characterized by a t (6;9) translocation resulting in an <i>MYB-NFIB</i> gene fusion or, more rarely, an <i>MYBL1</i> fusion. The true frequency and clinical significance of these alterations are still unclear. Here, we have used tissue microarrays and analyzed 391 ACCs and 647 non-ACC salivary neoplasms to study the prevalence, expression, and clinical significance of <i>MYB/MYBL1</i> alterations by FISH and immunohistochemistry. Alterations of <i>MYB</i> or <i>MYBL1</i> were found in 78% of the cases, of which 62% had <i>MYB</i> alterations and 16% had <i>MYBL1</i> rearrangements. Overexpression of MYB/MYBL1 oncoproteins was detected in 93% of the cases. <i>MYB</i> split signal, seen in 39% of the cases, was specifiCancersRearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study.PMC9367430AG-Fond FB17-22, FB20-91ALFGBG-9655372021-01-14:4CAN 21 1773Frierson HFEl-Naggar AKLoening TBrandwein-Weber MSFerrarotto RAndersson MKStenman GMitani YBoecker WPersson MMoskaluk CFonseca IfalseRearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study.Adenoid cystic carcinoma (ACC) is an aggressive head and neck malignancy characterized by a t (6;9) translocation resulting in an <i>MYB-NFIB</i> gene fusion or, more rarely, an <i>MYBL1</i> fusion. The true frequency and clinical significance of these alterations are still unclear. Here, we have used tissue microarrays and analyzed 391 ACCs and 647 non-ACC salivary neoplasms to study the prevalence, expression, and clinical significance of <i>MYB/MYBL1</i> alterations by FISH and immunohistochemistry. Alterations of <i>MYB</i> or <i>MYBL1</i> were found in 78% of the cases, of which 62% had <i>MYB</i> alterations and 16% had <i>MYBL1</i> rearrangements. Overexpression of MYB/MYBL1 oncoproteins was detected in 93% of the cases. <i>MYB</i> split signal, seen in 39% of the cases, was specifi2022-01-01T00:00:00Z2022 Jul2025-04-22T11:29:46.927Z2025-04-06T00:00:34.909ZS-EPMC93674303595435610.3390/cancers14153691