{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beirag N"],"funding":["Wellcome Trust"],"pagination":["960733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367475"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Lung surfactant protein D (SP-D) and Dendritic cell-specific intercellular adhesion molecules-3 grabbing non-integrin (DC-SIGN) are pathogen recognising C-type lectin receptors. SP-D has a crucial immune function in detecting and clearing pulmonary pathogens; DC-SIGN is involved in facilitating dendritic cell interaction with naïve T cells to mount an anti-viral immune response. SP-D and DC-SIGN have been shown to interact with various viruses, including SARS-CoV-2, an enveloped RNA virus that causes COVID-19. A recombinant fragment of human SP-D (rfhSP-D) comprising of α-helical neck region, carbohydrate recognition domain, and eight N-terminal Gly-X-Y repeats has been shown to bind SARS-CoV-2 Spike protein and inhibit SARS-CoV-2 replication by preventing viral entry in Vero cells and HEK"],"journal":["Frontiers in immunology"],"pubmed_title":["Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation."],"pmcid":["PMC9367475"],"funding_grant_id":["210183"],"pubmed_authors":["Varghese PM","Beirag N","Madan T","Idicula-Thomas S","Bulla R","Shamji MH","Kishore U","Murugaiah V","Neto MM","Kumar C","Mitchell D","Temperton N"],"additional_accession":[]},"is_claimable":false,"name":"Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation.","description":"Lung surfactant protein D (SP-D) and Dendritic cell-specific intercellular adhesion molecules-3 grabbing non-integrin (DC-SIGN) are pathogen recognising C-type lectin receptors. SP-D has a crucial immune function in detecting and clearing pulmonary pathogens; DC-SIGN is involved in facilitating dendritic cell interaction with naïve T cells to mount an anti-viral immune response. SP-D and DC-SIGN have been shown to interact with various viruses, including SARS-CoV-2, an enveloped RNA virus that causes COVID-19. A recombinant fragment of human SP-D (rfhSP-D) comprising of α-helical neck region, carbohydrate recognition domain, and eight N-terminal Gly-X-Y repeats has been shown to bind SARS-CoV-2 Spike protein and inhibit SARS-CoV-2 replication by preventing viral entry in Vero cells and HEK","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T08:01:36.567Z","creation":"2025-04-04T08:01:36.567Z"},"accession":"S-EPMC9367475","cross_references":{"pubmed":["35967323"],"doi":["10.3389/fimmu.2022.960733"]}}