{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu A"],"funding":["Shenzhen Second People’s Hospital"],"pagination":["487-500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9367658"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["White adipose tissue wasting plays a critical role in the development and progression of cancer cachexia. However, the mechanism behind the loss of adipose tissue remains ill-defined. In this study, we found that cancer cell-derived exosomes highly expressed miR-425-3p. Administration of cancer cell-derived exosomes significantly inhibited proliferation and differentiation of human preadipocytes-viscereal (HPA-v) cells. In mature adipocytes, cancer cell-derived exosomes activated cAMP/PKA signalling and lipophagy, leading to adipocyte lipolysis and browning of white adipocytes. These exosomes-induced alterations were almost abolished by endocytosis inhibitor cytochalasin D (CytoD) and antagomiR-425-3p, or reproduced by miR-425-3p mimics. In addition, bioinformatics analysis and luciferase "],"journal":["Adipocyte"],"pubmed_title":["Cancer cell-derived exosomal miR-425-3p induces white adipocyte atrophy."],"pmcid":["PMC9367658"],"funding_grant_id":["2019060014"],"pubmed_authors":["Pan W","Zhuang S","Zhang H","Liu A","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Cancer cell-derived exosomal miR-425-3p induces white adipocyte atrophy.","description":"White adipose tissue wasting plays a critical role in the development and progression of cancer cachexia. However, the mechanism behind the loss of adipose tissue remains ill-defined. In this study, we found that cancer cell-derived exosomes highly expressed miR-425-3p. Administration of cancer cell-derived exosomes significantly inhibited proliferation and differentiation of human preadipocytes-viscereal (HPA-v) cells. In mature adipocytes, cancer cell-derived exosomes activated cAMP/PKA signalling and lipophagy, leading to adipocyte lipolysis and browning of white adipocytes. These exosomes-induced alterations were almost abolished by endocytosis inhibitor cytochalasin D (CytoD) and antagomiR-425-3p, or reproduced by miR-425-3p mimics. In addition, bioinformatics analysis and luciferase ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T18:08:53.534Z","creation":"2025-04-07T05:43:13.405Z"},"accession":"S-EPMC9367658","cross_references":{"pubmed":["35941833"],"doi":["10.1080/21623945.2022.2108558"]}}